Family history and the risk of oral and pharyngeal cancer

Werner Garavello, Roberto Foschi, Renato Talamini, Carlo La Vecchia, Marta Rossi, Luigino Dal Maso, Alessandra Tavani, Fabio Levi, Luigi Barzan, Valerio Ramazzotti, Silvia Franceschi, Eva Negri

Research output: Contribution to journalArticle

Abstract

Scanty data are available on familial risk in oral and pharyngeal cancer. The relationship between oral and pharyngeal cancer and family history of cancer in first-degree relatives was investigated using data from a multicentric case-control study conducted in Italy and Switzerland between 1992 and 2005 on 956 cases aged less than 79 years, with histologically confirmed incident oral and pharyngeal cancer, and 2362 controls admitted to hospital for acute, nonneoplastic conditions. Logistic regression models conditioned on sex, age, study centre, and including terms for education, tobacco smoking, alcohol drinking, and number of siblings were used to estimate the odds ratios (OR) of oral and pharyngeal cancer. The multivariate ORs were similar for a family history of oral and pharyngeal cancer (2.6, 95% confidence interval, CI, 1.5-4.5) and laryngeal cancer (3.8, 95% CI, 2.0-7.2). The OR was 3.1 (95% CI, 2.0-4.8) for oral and pharyngeal cancer and laryngeal cancer combined. The OR was 7.1 (95% CI, 1.3-37.2) for subjects with 2 or more first-degree relatives with oral and pharyngeal/laryngeal cancers. Significant increases in risk were also observed for a family history of melanoma (OR = 5.8; 95% CI, 1.3-26.4) and lung cancer (OR = 1.4; 95% CI, 1.0-2.0). Compared to subjects without family history, nonsmokers, and non or moderate drinkers, the OR was 42.6 for current smokers, heavy drinkers with family history. History of oral and pharyngeal cancer and laryngeal cancer is a strong determinant of oral and pharyngeal cancer risk, independent from tobacco and alcohol.

Original languageEnglish
Pages (from-to)1827-1831
Number of pages5
JournalInternational Journal of Cancer
Volume122
Issue number8
DOIs
Publication statusPublished - Apr 15 2008

Keywords

  • Alcohol drinking
  • Familial risk
  • Oral neoplasms
  • Risk factors
  • Tobacco

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Fingerprint Dive into the research topics of 'Family history and the risk of oral and pharyngeal cancer'. Together they form a unique fingerprint.

  • Cite this

    Garavello, W., Foschi, R., Talamini, R., La Vecchia, C., Rossi, M., Dal Maso, L., Tavani, A., Levi, F., Barzan, L., Ramazzotti, V., Franceschi, S., & Negri, E. (2008). Family history and the risk of oral and pharyngeal cancer. International Journal of Cancer, 122(8), 1827-1831. https://doi.org/10.1002/ijc.23199