Family history of cancer and risk of breast cancer

Eva Negri, Claudia Braga, Carlo La Vecchia, Silvia Franceschi, Fabio Parazzini

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The relationship between breast cancer risk and family history of cancer in first-degree relatives was investigated using data from a multicentric case-control study conducted in Italy between June 1991 and April 1994 on 2,569 women aged less than 75 years, with histologically confirmed incident breast cancer, and 2,588 control women admitted to hospital for acute, non- neoplastic, non-gynaecological conditions. Relative to women with no history, those with a family history of breast cancer had an odds ratio (OR) of 2.4 [95% confidence interval (CI) 1.9-3.0], and those with family history of intestinal cancer had an OR of 1.3 (95% CI 1.0-1.7). No significant relations emerged between breast cancer risk and family history of prostate (OR 1.1), ovarian (OR 1.3), cervical or endometrial (OR 1.2) or other cancers, except gallbladder (OR 8.6). The OR for family history of any type of cancer except breast cancer was 1.1. For family history of breast cancer the ORs were similar across strata of age of the proband, being 2.4 below age 45, 2.2 at age 45-59 and 2.7 above age 60, and whether the relative affected was the mother, sister(s) or both, while the risk appeared higher if the age at onset of breast cancer in the relative was lower than 40 years (OR 3.5), rather than higher (OR 2.2). Thus, our results, based on the investigation of all neoplasms in first-degree relatives, confirm that breast cancer risk is increased in women with a family history of breast cancer, while there was no material association with family history of cancer in general, excluding breast cancer.

Original languageEnglish
Pages (from-to)735-738
Number of pages4
JournalInternational Journal of Cancer
Volume72
Issue number5
DOIs
Publication statusPublished - Sep 4 1997

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Breast Neoplasms
Odds Ratio
Confidence Intervals
Intestinal Neoplasms
Gallbladder Neoplasms
Neoplasms
Age of Onset
Italy
Case-Control Studies
Siblings
Prostate
History
Mothers

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Family history of cancer and risk of breast cancer. / Negri, Eva; Braga, Claudia; La Vecchia, Carlo; Franceschi, Silvia; Parazzini, Fabio.

In: International Journal of Cancer, Vol. 72, No. 5, 04.09.1997, p. 735-738.

Research output: Contribution to journalArticle

Negri, Eva ; Braga, Claudia ; La Vecchia, Carlo ; Franceschi, Silvia ; Parazzini, Fabio. / Family history of cancer and risk of breast cancer. In: International Journal of Cancer. 1997 ; Vol. 72, No. 5. pp. 735-738.
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