Family history of cancer and risk of ovarian cancer

E. Negri, C. Pelucchi, S. Franceschi, M. Montella, E. Conti, L. Dal Maso, F. Parazzini, A. Tavani, A. Carbone, C. La Vecchia

Research output: Contribution to journalArticlepeer-review


The aim of this study was to examine the relationship between history of cancer in first-degree relatives and ovarian cancer risk. Between 1992 and 1999, we conducted a case-control study in Italy on 1031 women with epithelial ovarian cancer and 2411 women admitted to hospital for acute non-neoplastic conditions. Odds ratios (OR) were estimated using unconditional logistic regression, adjusted for age and several potential confounders. Overall, 27 cases and nine controls reported a family history of ovarian cancer (OR=7.0; 95% confidence interval (CI) 3.1-16). The OR was 23 (95% CI 2.6-212) below age 50 years, based on 10 cases and one control only. The risk of ovarian cancer was also increased in women with a family history of cancer of the stomach (OR=1.5; 95% CI 1.0-2.1), intestine (OR=1.7; 95% CI 1.2-2.4), lung (OR=1.3; 95% CI 1.0-1.8), breast (OR=2.3; 95% CI 1.7-3.1), lymphomas (OR=2.3; 95% CI 1.0-5.1) and all sites (OR=1.6; 95% CI 1.4-1.9). Our results confirm the higher ovarian cancer risk in women with a family history of ovarian and breast cancer, and suggest a few associations with other sites.

Original languageEnglish
Pages (from-to)505-510
Number of pages6
JournalEuropean Journal of Cancer
Issue number4
Publication statusPublished - Mar 2003


  • Case-control study, Epidemiology, Family characteristics, Ovarian cancer

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology


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