Family history of cancer and the risk of bladder cancer: A case–control study from Italy

Federica Turati, Cristina Bosetti, Jerry Polesel, Diego Serraino, Maurizio Montella, Massimo Libra, Gaetano Facchini, Monica Ferraroni, Alessandra Tavani, Carlo La Vecchia, Eva Negri

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5 Citations (Scopus)

Abstract

Background A family history of bladder cancer has been associated with the risk of bladder cancer, but quantification of the excess risk in different populations is still a relevant issue. Further, the role of a family history of other cancers on the risk of bladder cancer remains unclear. Methods We analyzed data from an Italian case–control study, including 690 bladder cancer cases and 665 hospital controls. Odds ratios (ORs) were estimated through unconditional logistic regression models, adjusted for sex, age, study center, year of interview and further for education, smoking and sibling's number. Results The OR for family history of bladder cancer was 2.13 (95% confidence intervals (95%CIs) 1.02–4.49) from the model with partial adjustment, and 1.99 (95%CI 0.91–4.32) after additional adjustment for smoking and siblings’ number, based on 23 cases (3.3%) and 11 controls (1.7%) with a family history of bladder cancer. The fully adjusted OR was 3.77 when the relative was diagnosed at age below 65 years. Smokers with a family history of bladder cancer had a four-fold increased risk compared to non-smokers without a family history. Bladder cancer risk was significantly increased among subjects with a family history of hemolymphopoietic cancers (OR = 2.97, 95%CI 1.35–6.55). Family history of cancer at other sites showed no significant association with bladder cancer risk. Conclusion This study confirms an approximately two-fold increased risk of bladder cancer for family history of bladder cancer, and indicates a possible familial clustering of bladder cancer with cancers of the hemolymphopoietic system.

Original languageEnglish
Pages (from-to)29-35
Number of pages7
JournalCancer Epidemiology
Volume48
DOIs
Publication statusPublished - Jun 1 2017

Fingerprint

Urinary Bladder Neoplasms
Italy
Odds Ratio
Confidence Intervals
Neoplasms
Logistic Models
Smoking
Social Adjustment
Cluster Analysis
Interviews
Education

Keywords

  • Bladder cancer
  • Case–control study
  • Family history
  • Risk factors

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Cancer Research

Cite this

Family history of cancer and the risk of bladder cancer : A case–control study from Italy. / Turati, Federica; Bosetti, Cristina; Polesel, Jerry; Serraino, Diego; Montella, Maurizio; Libra, Massimo; Facchini, Gaetano; Ferraroni, Monica; Tavani, Alessandra; La Vecchia, Carlo; Negri, Eva.

In: Cancer Epidemiology, Vol. 48, 01.06.2017, p. 29-35.

Research output: Contribution to journalArticle

Turati, F, Bosetti, C, Polesel, J, Serraino, D, Montella, M, Libra, M, Facchini, G, Ferraroni, M, Tavani, A, La Vecchia, C & Negri, E 2017, 'Family history of cancer and the risk of bladder cancer: A case–control study from Italy', Cancer Epidemiology, vol. 48, pp. 29-35. https://doi.org/10.1016/j.canep.2017.03.003
Turati, Federica ; Bosetti, Cristina ; Polesel, Jerry ; Serraino, Diego ; Montella, Maurizio ; Libra, Massimo ; Facchini, Gaetano ; Ferraroni, Monica ; Tavani, Alessandra ; La Vecchia, Carlo ; Negri, Eva. / Family history of cancer and the risk of bladder cancer : A case–control study from Italy. In: Cancer Epidemiology. 2017 ; Vol. 48. pp. 29-35.
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abstract = "Background A family history of bladder cancer has been associated with the risk of bladder cancer, but quantification of the excess risk in different populations is still a relevant issue. Further, the role of a family history of other cancers on the risk of bladder cancer remains unclear. Methods We analyzed data from an Italian case–control study, including 690 bladder cancer cases and 665 hospital controls. Odds ratios (ORs) were estimated through unconditional logistic regression models, adjusted for sex, age, study center, year of interview and further for education, smoking and sibling's number. Results The OR for family history of bladder cancer was 2.13 (95{\%} confidence intervals (95{\%}CIs) 1.02–4.49) from the model with partial adjustment, and 1.99 (95{\%}CI 0.91–4.32) after additional adjustment for smoking and siblings’ number, based on 23 cases (3.3{\%}) and 11 controls (1.7{\%}) with a family history of bladder cancer. The fully adjusted OR was 3.77 when the relative was diagnosed at age below 65 years. Smokers with a family history of bladder cancer had a four-fold increased risk compared to non-smokers without a family history. Bladder cancer risk was significantly increased among subjects with a family history of hemolymphopoietic cancers (OR = 2.97, 95{\%}CI 1.35–6.55). Family history of cancer at other sites showed no significant association with bladder cancer risk. Conclusion This study confirms an approximately two-fold increased risk of bladder cancer for family history of bladder cancer, and indicates a possible familial clustering of bladder cancer with cancers of the hemolymphopoietic system.",
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T2 - A case–control study from Italy

AU - Turati, Federica

AU - Bosetti, Cristina

AU - Polesel, Jerry

AU - Serraino, Diego

AU - Montella, Maurizio

AU - Libra, Massimo

AU - Facchini, Gaetano

AU - Ferraroni, Monica

AU - Tavani, Alessandra

AU - La Vecchia, Carlo

AU - Negri, Eva

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N2 - Background A family history of bladder cancer has been associated with the risk of bladder cancer, but quantification of the excess risk in different populations is still a relevant issue. Further, the role of a family history of other cancers on the risk of bladder cancer remains unclear. Methods We analyzed data from an Italian case–control study, including 690 bladder cancer cases and 665 hospital controls. Odds ratios (ORs) were estimated through unconditional logistic regression models, adjusted for sex, age, study center, year of interview and further for education, smoking and sibling's number. Results The OR for family history of bladder cancer was 2.13 (95% confidence intervals (95%CIs) 1.02–4.49) from the model with partial adjustment, and 1.99 (95%CI 0.91–4.32) after additional adjustment for smoking and siblings’ number, based on 23 cases (3.3%) and 11 controls (1.7%) with a family history of bladder cancer. The fully adjusted OR was 3.77 when the relative was diagnosed at age below 65 years. Smokers with a family history of bladder cancer had a four-fold increased risk compared to non-smokers without a family history. Bladder cancer risk was significantly increased among subjects with a family history of hemolymphopoietic cancers (OR = 2.97, 95%CI 1.35–6.55). Family history of cancer at other sites showed no significant association with bladder cancer risk. Conclusion This study confirms an approximately two-fold increased risk of bladder cancer for family history of bladder cancer, and indicates a possible familial clustering of bladder cancer with cancers of the hemolymphopoietic system.

AB - Background A family history of bladder cancer has been associated with the risk of bladder cancer, but quantification of the excess risk in different populations is still a relevant issue. Further, the role of a family history of other cancers on the risk of bladder cancer remains unclear. Methods We analyzed data from an Italian case–control study, including 690 bladder cancer cases and 665 hospital controls. Odds ratios (ORs) were estimated through unconditional logistic regression models, adjusted for sex, age, study center, year of interview and further for education, smoking and sibling's number. Results The OR for family history of bladder cancer was 2.13 (95% confidence intervals (95%CIs) 1.02–4.49) from the model with partial adjustment, and 1.99 (95%CI 0.91–4.32) after additional adjustment for smoking and siblings’ number, based on 23 cases (3.3%) and 11 controls (1.7%) with a family history of bladder cancer. The fully adjusted OR was 3.77 when the relative was diagnosed at age below 65 years. Smokers with a family history of bladder cancer had a four-fold increased risk compared to non-smokers without a family history. Bladder cancer risk was significantly increased among subjects with a family history of hemolymphopoietic cancers (OR = 2.97, 95%CI 1.35–6.55). Family history of cancer at other sites showed no significant association with bladder cancer risk. Conclusion This study confirms an approximately two-fold increased risk of bladder cancer for family history of bladder cancer, and indicates a possible familial clustering of bladder cancer with cancers of the hemolymphopoietic system.

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