Family history of cancer and the risk of bladder cancer: A case–control study from Italy

F. Turati, C. Bosetti, J. Polesel, D. Serraino, M. Montella, M. Libra, G. Facchini, M. Ferraroni, A. Tavani, C. La Vecchia, E. Negri

Research output: Contribution to journalArticlepeer-review


Background A family history of bladder cancer has been associated with the risk of bladder cancer, but quantification of the excess risk in different populations is still a relevant issue. Further, the role of a family history of other cancers on the risk of bladder cancer remains unclear. Methods We analyzed data from an Italian case–control study, including 690 bladder cancer cases and 665 hospital controls. Odds ratios (ORs) were estimated through unconditional logistic regression models, adjusted for sex, age, study center, year of interview and further for education, smoking and sibling's number. Results The OR for family history of bladder cancer was 2.13 (95% confidence intervals (95%CIs) 1.02–4.49) from the model with partial adjustment, and 1.99 (95%CI 0.91–4.32) after additional adjustment for smoking and siblings’ number, based on 23 cases (3.3%) and 11 controls (1.7%) with a family history of bladder cancer. The fully adjusted OR was 3.77 when the relative was diagnosed at age below 65 years. Smokers with a family history of bladder cancer had a four-fold increased risk compared to non-smokers without a family history. Bladder cancer risk was significantly increased among subjects with a family history of hemolymphopoietic cancers (OR = 2.97, 95%CI 1.35–6.55). Family history of cancer at other sites showed no significant association with bladder cancer risk. Conclusion This study confirms an approximately two-fold increased risk of bladder cancer for family history of bladder cancer, and indicates a possible familial clustering of bladder cancer with cancers of the hemolymphopoietic system. © 2017 Elsevier Ltd
Original languageEnglish
Pages (from-to)29-35
Number of pages7
JournalCancer Epidemiology
Publication statusPublished - 2017


  • Bladder cancer
  • Case–control study
  • Family history
  • Risk factors
  • adult
  • age
  • aged
  • Article
  • bladder cancer
  • bone cancer
  • brain cancer
  • breast cancer
  • case control study
  • clinical article
  • colorectal cancer
  • confidence interval
  • controlled study
  • education
  • family history
  • female
  • hematologic malignancy
  • hereditary tumor
  • human
  • interview
  • Italy
  • kidney cancer
  • liver cancer
  • logistic regression analysis
  • lung cancer
  • male
  • mouth cancer
  • pancreas cancer
  • pharynx cancer
  • priority journal
  • prostate cancer
  • relative
  • risk assessment
  • sibling
  • smoking
  • stomach cancer
  • uterus cancer
  • anamnesis
  • middle aged
  • risk factor
  • statistics and numerical data
  • Urinary Bladder Neoplasms
  • very elderly
  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Female
  • Humans
  • Male
  • Medical History Taking
  • Middle Aged
  • Risk Factors


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