Family history of cancer and the risk of cancer: A network of case-control studies

F. Turati, V. Edefonti, C. Bosetti, M. Ferraroni, M. Malvezzi, S. Franceschi, R. Talamini, M. Montella, F. Levi, L. Dal Maso, D. Serraino, J. Polesel, E. Negri, A. Decarli, C. La Vecchia

Research output: Contribution to journalArticlepeer-review


Background: The risk of many cancers is higher in subjects with a family history (FH) of cancer at a concordant site. However, few studies investigated FH of cancer at discordant sites. Patients and methods: This study is based on a network of Italian and Swiss case-control studies on 13 cancer sites conducted between 1991 and 2009, and including more than 12 000 cases and 11 000 controls. We collected information on history of any cancer in first degree relatives, and age at diagnosis. Odds ratios (ORs) for FH were calculated by multiple logistic regression models, adjusted for major confounding factors. Results: All sites showed an excess risk in relation to FH of cancer at the same site. Increased risks were also found for oral and pharyngeal cancer and FH of laryngeal cancer (OR = 3.3), esophageal cancer and FH of oral and pharyngeal cancer (OR = 4.1), breast cancer and FH of colorectal cancer (OR = 1.5) and of hemolymphopoietic cancers (OR = 1.7), ovarian cancer and FH of breast cancer(OR = 2.3), and prostate cancer and FH of bladder cancer (OR = 3.4). For most cancer sites, the association with FH was stronger when the proband was affected at age

Original languageEnglish
Pages (from-to)2651-2656
Number of pages6
JournalAnnals of Oncology
Issue number10
Publication statusPublished - Oct 2013


  • Cancer
  • Case-Control study
  • Epidemiology
  • Family history
  • Risk factors

ASJC Scopus subject areas

  • Oncology
  • Hematology

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