Family history of cancer and the risk of endometrial cancer

Ersilia Lucenteforte, Renato Talamini, Maurizio Montella, Luigino Dal Maso, Claudio Pelucchi, Silvia Franceschi, Carlo La Vecchia, Eva Negri

Research output: Contribution to journalArticlepeer-review


To investigate the relationship between family history of cancer in first-degree relatives and the risk of endometrial cancer, we carried out a large multicentre case-control study in Italy between 1992 and 2006, including 454 endometrial cancer cases and 908 controls admitted in hospital for acute, non-neoplastic diseases. Conditional logistic regression was used to estimate odds ratios (ORs) and corresponding 95% confidence intervals (Cl). Relative to women with no family history of uterine cancer, the ORs were 2.1 (95% Cl: 0.7-6.4) for those reporting a family history of endometrial cancer and 1.8 (95% Cl: 1.0-3.2) for a family history of any uterine cancer. A family history of intestinal cancer was directly associated with endometrial cancer risk (OR=1.6; 95% Cl: 1.0-2.7). Direct associations were found for a few other cancer sites. In conclusion, a family history of endometrial, uterine or intestinal cancer in first-degree relatives is associated with an increased risk of endometrial cancer.

Original languageEnglish
Pages (from-to)95-99
Number of pages5
JournalEuropean Journal of Cancer Prevention
Issue number2
Publication statusPublished - Apr 2009


  • Case-control study
  • Endometrial cancer
  • Family history
  • Risk

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Epidemiology
  • Public Health, Environmental and Occupational Health


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