Abstract
A role for genetic susceptibility in non-Hodgkin lymphoma (NHL) is supported by the accumulating evidence of common genetic variations altering NHL risk. However, the pattern of NHL heritability remains poorly understood. We conducted a pooled analysis of 10 211 NHL cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph) to evaluate NHL risk among those with hematopoietic malignancies in first-degree relatives. Odds ratios (ORs) and 95% confidence intervals (CIs) of NHL and its subtypes were estimated from unconditional logistic regression models with adjustment for confounders. NHL risk was elevated for individuals who reported first-degree relatives with NHL (OR = 1.5; 95% CI = 1.2-1.9), Hodgkin lymphoma (OR = 1.6; 95% CI = 1.1-2.3), and leukemia (OR = 1.4; 95% CI = 1.2-2.7). Risk was highest among individuals who reported a brother with NHL (OR = 2.8; 95% CI = 1.6-4.8) and was consistent for all NHL subtypes evaluated. If a first-degree relative had Hodgkin lymphoma, NHL risk was highest if the relative was a parent (OR = 1.7; 95% CI = 1.0-2.9). If a first-degree relative had leukemia, NHL risk was highest among women who reported a sister with leukemia (OR = 3.0; 95% CI = 1.6-5.6). The pattern of NHL heritability appeared to be uniform across NHL subtypes, but risk patterns differed by specific hematopoietic malignancies and the sex of the relative, revealing critical clues to disease etiology.
| Original language | English |
|---|---|
| Pages (from-to) | 3479-3488 |
| Number of pages | 10 |
| Journal | Blood |
| Volume | 109 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Apr 15 2007 |
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ASJC Scopus subject areas
- Hematology
Cite this
Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL) : A pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph). / Wang, Sophia S.; Slager, Susan L.; Brennan, Paul; Holly, Elizabeth A.; De Sanjose, Silvia; Bernstein, Leslie; Boffetta, Paolo; Cerhan, James R.; Maynadie, Marc; Spinelli, John J.; Chiu, Brian C H; Cocco, Pier Luigi; Mensah, Fiona; Zhang, Yawei; Nieters, Alexandra; Dal Maso, Luigino; Bracci, Paige M.; Costantini, Adele Seniori; Vineis, Paolo; Severson, Richard K.; Roman, Eve; Cozen, Wendy; Weisenburger, Dennis; Davis, Scott; Franceschi, Silvia; La Vecchia, Carlo; Foretova, Lenka; Becker, Nikolaus; Staines, Anthony; Vornanen, Martine; Zheng, Tongzhang; Hartge, Patricia.
In: Blood, Vol. 109, No. 8, 15.04.2007, p. 3479-3488.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL)
T2 - A pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph)
AU - Wang, Sophia S.
AU - Slager, Susan L.
AU - Brennan, Paul
AU - Holly, Elizabeth A.
AU - De Sanjose, Silvia
AU - Bernstein, Leslie
AU - Boffetta, Paolo
AU - Cerhan, James R.
AU - Maynadie, Marc
AU - Spinelli, John J.
AU - Chiu, Brian C H
AU - Cocco, Pier Luigi
AU - Mensah, Fiona
AU - Zhang, Yawei
AU - Nieters, Alexandra
AU - Dal Maso, Luigino
AU - Bracci, Paige M.
AU - Costantini, Adele Seniori
AU - Vineis, Paolo
AU - Severson, Richard K.
AU - Roman, Eve
AU - Cozen, Wendy
AU - Weisenburger, Dennis
AU - Davis, Scott
AU - Franceschi, Silvia
AU - La Vecchia, Carlo
AU - Foretova, Lenka
AU - Becker, Nikolaus
AU - Staines, Anthony
AU - Vornanen, Martine
AU - Zheng, Tongzhang
AU - Hartge, Patricia
PY - 2007/4/15
Y1 - 2007/4/15
N2 - A role for genetic susceptibility in non-Hodgkin lymphoma (NHL) is supported by the accumulating evidence of common genetic variations altering NHL risk. However, the pattern of NHL heritability remains poorly understood. We conducted a pooled analysis of 10 211 NHL cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph) to evaluate NHL risk among those with hematopoietic malignancies in first-degree relatives. Odds ratios (ORs) and 95% confidence intervals (CIs) of NHL and its subtypes were estimated from unconditional logistic regression models with adjustment for confounders. NHL risk was elevated for individuals who reported first-degree relatives with NHL (OR = 1.5; 95% CI = 1.2-1.9), Hodgkin lymphoma (OR = 1.6; 95% CI = 1.1-2.3), and leukemia (OR = 1.4; 95% CI = 1.2-2.7). Risk was highest among individuals who reported a brother with NHL (OR = 2.8; 95% CI = 1.6-4.8) and was consistent for all NHL subtypes evaluated. If a first-degree relative had Hodgkin lymphoma, NHL risk was highest if the relative was a parent (OR = 1.7; 95% CI = 1.0-2.9). If a first-degree relative had leukemia, NHL risk was highest among women who reported a sister with leukemia (OR = 3.0; 95% CI = 1.6-5.6). The pattern of NHL heritability appeared to be uniform across NHL subtypes, but risk patterns differed by specific hematopoietic malignancies and the sex of the relative, revealing critical clues to disease etiology.
AB - A role for genetic susceptibility in non-Hodgkin lymphoma (NHL) is supported by the accumulating evidence of common genetic variations altering NHL risk. However, the pattern of NHL heritability remains poorly understood. We conducted a pooled analysis of 10 211 NHL cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph) to evaluate NHL risk among those with hematopoietic malignancies in first-degree relatives. Odds ratios (ORs) and 95% confidence intervals (CIs) of NHL and its subtypes were estimated from unconditional logistic regression models with adjustment for confounders. NHL risk was elevated for individuals who reported first-degree relatives with NHL (OR = 1.5; 95% CI = 1.2-1.9), Hodgkin lymphoma (OR = 1.6; 95% CI = 1.1-2.3), and leukemia (OR = 1.4; 95% CI = 1.2-2.7). Risk was highest among individuals who reported a brother with NHL (OR = 2.8; 95% CI = 1.6-4.8) and was consistent for all NHL subtypes evaluated. If a first-degree relative had Hodgkin lymphoma, NHL risk was highest if the relative was a parent (OR = 1.7; 95% CI = 1.0-2.9). If a first-degree relative had leukemia, NHL risk was highest among women who reported a sister with leukemia (OR = 3.0; 95% CI = 1.6-5.6). The pattern of NHL heritability appeared to be uniform across NHL subtypes, but risk patterns differed by specific hematopoietic malignancies and the sex of the relative, revealing critical clues to disease etiology.
UR - http://www.scopus.com/inward/record.url?scp=34147154891&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34147154891&partnerID=8YFLogxK
U2 - 10.1182/blood-2006-06-031948
DO - 10.1182/blood-2006-06-031948
M3 - Article
C2 - 17185468
AN - SCOPUS:34147154891
VL - 109
SP - 3479
EP - 3488
JO - Blood
JF - Blood
SN - 0006-4971
IS - 8
ER -