Family history of panic disorder and hypersensitivity to CO 2 in patients with panic disorder

Giampaolo Perna, Angelo Bertani, Daniela Caldirola, Laura Bellodi

Research output: Contribution to journalArticle

Abstract

Objective: The authors investigated the relationships between hypersensitivity to CO 2 and familial-genetic risk for panic disorder in patients with panic disorder. Method: Morbidity risks for panic disorder were calculated for families of 203 patients with panic disorder, each of whom was challenged with 35% CO 2. Results: Patients who reacted with a positive response to the 35% CO 2 challenge showed a genetic risk for panic disorder (morbidity risk = 14.4%) that was significantly higher than that for patients who did not react (morbidity risk=3.9%). Conclusions: These findings support the idea that hypersensitivity to CO 2 might be associated with a subtype of panic disorder specifically related to a greater familial loading.

Original languageEnglish
Pages (from-to)1060-1064
Number of pages5
JournalAmerican Journal of Psychiatry
Volume153
Issue number8
Publication statusPublished - Aug 1996

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Perna, G., Bertani, A., Caldirola, D., & Bellodi, L. (1996). Family history of panic disorder and hypersensitivity to CO 2 in patients with panic disorder. American Journal of Psychiatry, 153(8), 1060-1064.