Fanconi anemia - learning from children

Johanna Svahn, Carlo Dufour

Research output: Contribution to journalArticlepeer-review


Fanconi Anemia (FA) is a rare autosomic recessive and X-linked disease with chromosomal instability after exposure to crosslinking agents as the hallmark. Clinical features of FA are somatic malformations, progressive bone marrow failure and cancer proneness, however there is wide clinical heterogeneity. The symptom most frequently and early associated with morbidity and mortality is progressive pancytopenia in the first decade of life although acute myelogenous leukemia (AML) or myelodysplastic syndrome (MDS) can appear before aplastic anemia. Squamous cell carcinoma (SCC) of the head-neck, intestinal or genital tract has a very high incidence in FA and can appear at young age. This paper will focus on treatment of bone marrow failure in FA.

Original languageEnglish
Article numbere8
Pages (from-to)18-20
Number of pages3
JournalPediatric Reports
Issue number2S
Publication statusPublished - 2011


  • Anemia
  • Fanconi

ASJC Scopus subject areas

  • Pediatrics


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