Farmers develop more aggressive histologic subtypes of basal cell carcinoma. Experience from a Tertiary Hospital in Northern Greece

Z. Apalla, A. Lallas, E. Sotiriou, E. Lazaridou, E. Vakirlis, M. Trakatelli, A. Kyrgidis, D. Ioannides

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background Ultraviolet radiation plays an important role in the pathogenesis of non-melanoma skin cancer. Outdoor workers, including farmers, experience higher exposure levels compared to the general population. Available literature data suggest that occupational ultraviolet exposure represents an independent risk factor for squamous cell carcinoma; whereas for basal cell carcinoma (BCC) this association still remains unclarified. Objectives To analyse the epidemiological, clinical and histological data of patients diagnosed with BCC, and correlate them with outdoor occupation in farmers. Methods Individuals with histologically diagnosed BCCs, between September 2013 and September 2015, were included in the study. Their medical data, including epidemiological, clinical and histological characteristics, were recorded and analysed in conjunction with the occupation. Farmers were identified based on their specific public health insurance. Results Three hundred and forty patients, with 542 BCCs were included in the study. One hundred and twenty (35.3%) were farmers. Mean age of farmers was lower than non-farmers (66.0 ± 9.1 years vs. 75 ± 6.6 years, Mann-Whitney U-test, P <0.001). Farmers had a sixfold higher probability for exhibiting photodamaged skin (OR = 6.02, 95% CI: 3.66-9.90, P <0.001). Farmer workers were more likely to exhibit infiltrative or morpheaform BCC, but less likely to develop superficial BCC. Conclusion Our results indicate a higher risk of earlier development of more aggressive histological subtypes of BCCs in farmers. Photodamage was also more common in this group. Primary and secondary prevention strategies focusing on outdoor workers, including farmers, are mandatory.

Original languageEnglish
Pages (from-to)17-20
Number of pages4
JournalJournal of the European Academy of Dermatology and Venereology
Volume30
DOIs
Publication statusPublished - Apr 1 2016

Fingerprint

Basal Cell Carcinoma
Greece
Tertiary Care Centers
Occupations
Background Radiation
Farmers
Skin Neoplasms
Occupational Exposure
Primary Prevention
Health Insurance
Nonparametric Statistics
Secondary Prevention
Squamous Cell Carcinoma
Public Health
Skin

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

Cite this

Farmers develop more aggressive histologic subtypes of basal cell carcinoma. Experience from a Tertiary Hospital in Northern Greece. / Apalla, Z.; Lallas, A.; Sotiriou, E.; Lazaridou, E.; Vakirlis, E.; Trakatelli, M.; Kyrgidis, A.; Ioannides, D.

In: Journal of the European Academy of Dermatology and Venereology, Vol. 30, 01.04.2016, p. 17-20.

Research output: Contribution to journalArticle

Apalla, Z. ; Lallas, A. ; Sotiriou, E. ; Lazaridou, E. ; Vakirlis, E. ; Trakatelli, M. ; Kyrgidis, A. ; Ioannides, D. / Farmers develop more aggressive histologic subtypes of basal cell carcinoma. Experience from a Tertiary Hospital in Northern Greece. In: Journal of the European Academy of Dermatology and Venereology. 2016 ; Vol. 30. pp. 17-20.
@article{1dd7f4a80f7b48d6ba7cf28207df63b3,
title = "Farmers develop more aggressive histologic subtypes of basal cell carcinoma. Experience from a Tertiary Hospital in Northern Greece",
abstract = "Background Ultraviolet radiation plays an important role in the pathogenesis of non-melanoma skin cancer. Outdoor workers, including farmers, experience higher exposure levels compared to the general population. Available literature data suggest that occupational ultraviolet exposure represents an independent risk factor for squamous cell carcinoma; whereas for basal cell carcinoma (BCC) this association still remains unclarified. Objectives To analyse the epidemiological, clinical and histological data of patients diagnosed with BCC, and correlate them with outdoor occupation in farmers. Methods Individuals with histologically diagnosed BCCs, between September 2013 and September 2015, were included in the study. Their medical data, including epidemiological, clinical and histological characteristics, were recorded and analysed in conjunction with the occupation. Farmers were identified based on their specific public health insurance. Results Three hundred and forty patients, with 542 BCCs were included in the study. One hundred and twenty (35.3{\%}) were farmers. Mean age of farmers was lower than non-farmers (66.0 ± 9.1 years vs. 75 ± 6.6 years, Mann-Whitney U-test, P <0.001). Farmers had a sixfold higher probability for exhibiting photodamaged skin (OR = 6.02, 95{\%} CI: 3.66-9.90, P <0.001). Farmer workers were more likely to exhibit infiltrative or morpheaform BCC, but less likely to develop superficial BCC. Conclusion Our results indicate a higher risk of earlier development of more aggressive histological subtypes of BCCs in farmers. Photodamage was also more common in this group. Primary and secondary prevention strategies focusing on outdoor workers, including farmers, are mandatory.",
author = "Z. Apalla and A. Lallas and E. Sotiriou and E. Lazaridou and E. Vakirlis and M. Trakatelli and A. Kyrgidis and D. Ioannides",
year = "2016",
month = "4",
day = "1",
doi = "10.1111/jdv.13605",
language = "English",
volume = "30",
pages = "17--20",
journal = "Journal of the European Academy of Dermatology and Venereology",
issn = "0926-9959",
publisher = "wiley",

}

TY - JOUR

T1 - Farmers develop more aggressive histologic subtypes of basal cell carcinoma. Experience from a Tertiary Hospital in Northern Greece

AU - Apalla, Z.

AU - Lallas, A.

AU - Sotiriou, E.

AU - Lazaridou, E.

AU - Vakirlis, E.

AU - Trakatelli, M.

AU - Kyrgidis, A.

AU - Ioannides, D.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Background Ultraviolet radiation plays an important role in the pathogenesis of non-melanoma skin cancer. Outdoor workers, including farmers, experience higher exposure levels compared to the general population. Available literature data suggest that occupational ultraviolet exposure represents an independent risk factor for squamous cell carcinoma; whereas for basal cell carcinoma (BCC) this association still remains unclarified. Objectives To analyse the epidemiological, clinical and histological data of patients diagnosed with BCC, and correlate them with outdoor occupation in farmers. Methods Individuals with histologically diagnosed BCCs, between September 2013 and September 2015, were included in the study. Their medical data, including epidemiological, clinical and histological characteristics, were recorded and analysed in conjunction with the occupation. Farmers were identified based on their specific public health insurance. Results Three hundred and forty patients, with 542 BCCs were included in the study. One hundred and twenty (35.3%) were farmers. Mean age of farmers was lower than non-farmers (66.0 ± 9.1 years vs. 75 ± 6.6 years, Mann-Whitney U-test, P <0.001). Farmers had a sixfold higher probability for exhibiting photodamaged skin (OR = 6.02, 95% CI: 3.66-9.90, P <0.001). Farmer workers were more likely to exhibit infiltrative or morpheaform BCC, but less likely to develop superficial BCC. Conclusion Our results indicate a higher risk of earlier development of more aggressive histological subtypes of BCCs in farmers. Photodamage was also more common in this group. Primary and secondary prevention strategies focusing on outdoor workers, including farmers, are mandatory.

AB - Background Ultraviolet radiation plays an important role in the pathogenesis of non-melanoma skin cancer. Outdoor workers, including farmers, experience higher exposure levels compared to the general population. Available literature data suggest that occupational ultraviolet exposure represents an independent risk factor for squamous cell carcinoma; whereas for basal cell carcinoma (BCC) this association still remains unclarified. Objectives To analyse the epidemiological, clinical and histological data of patients diagnosed with BCC, and correlate them with outdoor occupation in farmers. Methods Individuals with histologically diagnosed BCCs, between September 2013 and September 2015, were included in the study. Their medical data, including epidemiological, clinical and histological characteristics, were recorded and analysed in conjunction with the occupation. Farmers were identified based on their specific public health insurance. Results Three hundred and forty patients, with 542 BCCs were included in the study. One hundred and twenty (35.3%) were farmers. Mean age of farmers was lower than non-farmers (66.0 ± 9.1 years vs. 75 ± 6.6 years, Mann-Whitney U-test, P <0.001). Farmers had a sixfold higher probability for exhibiting photodamaged skin (OR = 6.02, 95% CI: 3.66-9.90, P <0.001). Farmer workers were more likely to exhibit infiltrative or morpheaform BCC, but less likely to develop superficial BCC. Conclusion Our results indicate a higher risk of earlier development of more aggressive histological subtypes of BCCs in farmers. Photodamage was also more common in this group. Primary and secondary prevention strategies focusing on outdoor workers, including farmers, are mandatory.

UR - http://www.scopus.com/inward/record.url?scp=84962521936&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84962521936&partnerID=8YFLogxK

U2 - 10.1111/jdv.13605

DO - 10.1111/jdv.13605

M3 - Article

VL - 30

SP - 17

EP - 20

JO - Journal of the European Academy of Dermatology and Venereology

JF - Journal of the European Academy of Dermatology and Venereology

SN - 0926-9959

ER -