Fas and Fas ligand-mediated apoptosis and its role in autoimmune diabetes

Alberto Signore, Alessio Annovazzi, Roberto Gradini, Roberto Liddi, Giovina Ruberti

Research output: Contribution to journalArticle

Abstract

The relationship between Fas-mediated apoptosis and Type 1 diabetes is currently under investigation. Fas/Fas ligand interaction could be involved both in the insulitis process and in β-cell death. Nevertheless, different mechanisms appear to be involved in human Type 1 diabetes and in NOD mice. In the present work, we review recent evidence of the role of the Fas/Fas ligand system in human and NOD mouse diabetes, describing possible hypotheses for its involvement in the pathogenesis of the disease, with possible implications for therapy and islet transplantation.

Original languageEnglish
Pages (from-to)197-206
Number of pages10
JournalDiabetes/Metabolism Reviews
Volume14
Issue number3
DOIs
Publication statusPublished - Sep 1998

Keywords

  • Apoptosis
  • Fas
  • Fas ligand
  • Islets of Langherans

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Biochemistry

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