Fas-FasL interactions: A common pathogenetic mechanism in organ-specific autoimmunity

Ruggero De Maria, Roberto Testi

Research output: Contribution to journalArticlepeer-review


Organ-specific autoimmunity is characterized by the accelerated loss of selected cell types, resulting in specific tissue destruction and disease. The role of different genetic or environmental factors in initiating the autoimmune reactivity is still unclear. However, novel mechanisms responsible for tissue destruction have recently been revealed. Here, Ruggero De Maria and Roberto Testi propose that Fas ligand may represent a common weapon during the destructive phase of organ-specific autoimmunity.

Original languageEnglish
Pages (from-to)121-125
Number of pages5
JournalImmunology Today
Issue number3
Publication statusPublished - Mar 1 1998

ASJC Scopus subject areas

  • Immunology


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