Fas-mediated T-cell apoptosis is impaired in patients with chronic inflammatory demyelinating polyneuropathy

Cristoforo Comi, Paola Gaviani, Maurizio Leone, Massimo Ferretti, Luca Castelli, Riccardo Mesturini, Gianluca Ubezio, Annalisa Chiocchetti, Maurizio Osio, Francesco Muscia, Graziella Bogliun, Giovanni Corso, Armando Gavazzi, Claudio Mariani, Roberto Cantello, Francesco Monaco, Umberto Dianzani

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The Fas death receptor is expressed by activated lymphocytes and is involved in switching-off the immune response. Its inherited defects cause auto-immune lymphoproliferative syndrome. Impaired Fas function may also play a role in other auto-immune diseases, such as multiple sclerosis and type 1 diabetes mellitus. The aim of this work was to evaluate Fas function in T cells from patients with chronic inflammatory demyelinating polyneuropathy (CIDP). We evaluated Fas-induced apoptosis in T-cell lines from 27 patients with CIDP, 12 patients with acute inflammatory demyelinating polyneuropathy (AIDP), and 110 controls. CIDP patients displayed lower Fas function than both AIDP patients and controls, whereas no statistically significant difference was found between AIDP patients and controls. Moreover, Fas function was lower in CIDP patients with progressive course than in those with relapsing-remitting course and lower in CIDP patients with axonal damage than in those with pure demyelination. These data suggest that defective Fas function favours CIDP development and aggressive evolution.

Original languageEnglish
Pages (from-to)53-60
Number of pages8
JournalJournal of the Peripheral Nervous System
Volume11
Issue number1
DOIs
Publication statusPublished - Mar 2006

Fingerprint

Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Apoptosis
T-Lymphocytes
Guillain-Barre Syndrome
CD95 Antigens
Death Domain Receptors
Immune System Diseases
Demyelinating Diseases
Type 1 Diabetes Mellitus
Multiple Sclerosis
Lymphocytes
Cell Line

Keywords

  • Auto-immunity
  • Fas
  • Peripheral neuropathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Fas-mediated T-cell apoptosis is impaired in patients with chronic inflammatory demyelinating polyneuropathy. / Comi, Cristoforo; Gaviani, Paola; Leone, Maurizio; Ferretti, Massimo; Castelli, Luca; Mesturini, Riccardo; Ubezio, Gianluca; Chiocchetti, Annalisa; Osio, Maurizio; Muscia, Francesco; Bogliun, Graziella; Corso, Giovanni; Gavazzi, Armando; Mariani, Claudio; Cantello, Roberto; Monaco, Francesco; Dianzani, Umberto.

In: Journal of the Peripheral Nervous System, Vol. 11, No. 1, 03.2006, p. 53-60.

Research output: Contribution to journalArticle

Comi, C, Gaviani, P, Leone, M, Ferretti, M, Castelli, L, Mesturini, R, Ubezio, G, Chiocchetti, A, Osio, M, Muscia, F, Bogliun, G, Corso, G, Gavazzi, A, Mariani, C, Cantello, R, Monaco, F & Dianzani, U 2006, 'Fas-mediated T-cell apoptosis is impaired in patients with chronic inflammatory demyelinating polyneuropathy', Journal of the Peripheral Nervous System, vol. 11, no. 1, pp. 53-60. https://doi.org/10.1111/j.1085-9489.2006.00063.x
Comi, Cristoforo ; Gaviani, Paola ; Leone, Maurizio ; Ferretti, Massimo ; Castelli, Luca ; Mesturini, Riccardo ; Ubezio, Gianluca ; Chiocchetti, Annalisa ; Osio, Maurizio ; Muscia, Francesco ; Bogliun, Graziella ; Corso, Giovanni ; Gavazzi, Armando ; Mariani, Claudio ; Cantello, Roberto ; Monaco, Francesco ; Dianzani, Umberto. / Fas-mediated T-cell apoptosis is impaired in patients with chronic inflammatory demyelinating polyneuropathy. In: Journal of the Peripheral Nervous System. 2006 ; Vol. 11, No. 1. pp. 53-60.
@article{fc19a0fa757946f08d5ae57336e3ab33,
title = "Fas-mediated T-cell apoptosis is impaired in patients with chronic inflammatory demyelinating polyneuropathy",
abstract = "The Fas death receptor is expressed by activated lymphocytes and is involved in switching-off the immune response. Its inherited defects cause auto-immune lymphoproliferative syndrome. Impaired Fas function may also play a role in other auto-immune diseases, such as multiple sclerosis and type 1 diabetes mellitus. The aim of this work was to evaluate Fas function in T cells from patients with chronic inflammatory demyelinating polyneuropathy (CIDP). We evaluated Fas-induced apoptosis in T-cell lines from 27 patients with CIDP, 12 patients with acute inflammatory demyelinating polyneuropathy (AIDP), and 110 controls. CIDP patients displayed lower Fas function than both AIDP patients and controls, whereas no statistically significant difference was found between AIDP patients and controls. Moreover, Fas function was lower in CIDP patients with progressive course than in those with relapsing-remitting course and lower in CIDP patients with axonal damage than in those with pure demyelination. These data suggest that defective Fas function favours CIDP development and aggressive evolution.",
keywords = "Auto-immunity, Fas, Peripheral neuropathy",
author = "Cristoforo Comi and Paola Gaviani and Maurizio Leone and Massimo Ferretti and Luca Castelli and Riccardo Mesturini and Gianluca Ubezio and Annalisa Chiocchetti and Maurizio Osio and Francesco Muscia and Graziella Bogliun and Giovanni Corso and Armando Gavazzi and Claudio Mariani and Roberto Cantello and Francesco Monaco and Umberto Dianzani",
year = "2006",
month = "3",
doi = "10.1111/j.1085-9489.2006.00063.x",
language = "English",
volume = "11",
pages = "53--60",
journal = "Journal of the Peripheral Nervous System",
issn = "1085-9489",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Fas-mediated T-cell apoptosis is impaired in patients with chronic inflammatory demyelinating polyneuropathy

AU - Comi, Cristoforo

AU - Gaviani, Paola

AU - Leone, Maurizio

AU - Ferretti, Massimo

AU - Castelli, Luca

AU - Mesturini, Riccardo

AU - Ubezio, Gianluca

AU - Chiocchetti, Annalisa

AU - Osio, Maurizio

AU - Muscia, Francesco

AU - Bogliun, Graziella

AU - Corso, Giovanni

AU - Gavazzi, Armando

AU - Mariani, Claudio

AU - Cantello, Roberto

AU - Monaco, Francesco

AU - Dianzani, Umberto

PY - 2006/3

Y1 - 2006/3

N2 - The Fas death receptor is expressed by activated lymphocytes and is involved in switching-off the immune response. Its inherited defects cause auto-immune lymphoproliferative syndrome. Impaired Fas function may also play a role in other auto-immune diseases, such as multiple sclerosis and type 1 diabetes mellitus. The aim of this work was to evaluate Fas function in T cells from patients with chronic inflammatory demyelinating polyneuropathy (CIDP). We evaluated Fas-induced apoptosis in T-cell lines from 27 patients with CIDP, 12 patients with acute inflammatory demyelinating polyneuropathy (AIDP), and 110 controls. CIDP patients displayed lower Fas function than both AIDP patients and controls, whereas no statistically significant difference was found between AIDP patients and controls. Moreover, Fas function was lower in CIDP patients with progressive course than in those with relapsing-remitting course and lower in CIDP patients with axonal damage than in those with pure demyelination. These data suggest that defective Fas function favours CIDP development and aggressive evolution.

AB - The Fas death receptor is expressed by activated lymphocytes and is involved in switching-off the immune response. Its inherited defects cause auto-immune lymphoproliferative syndrome. Impaired Fas function may also play a role in other auto-immune diseases, such as multiple sclerosis and type 1 diabetes mellitus. The aim of this work was to evaluate Fas function in T cells from patients with chronic inflammatory demyelinating polyneuropathy (CIDP). We evaluated Fas-induced apoptosis in T-cell lines from 27 patients with CIDP, 12 patients with acute inflammatory demyelinating polyneuropathy (AIDP), and 110 controls. CIDP patients displayed lower Fas function than both AIDP patients and controls, whereas no statistically significant difference was found between AIDP patients and controls. Moreover, Fas function was lower in CIDP patients with progressive course than in those with relapsing-remitting course and lower in CIDP patients with axonal damage than in those with pure demyelination. These data suggest that defective Fas function favours CIDP development and aggressive evolution.

KW - Auto-immunity

KW - Fas

KW - Peripheral neuropathy

UR - http://www.scopus.com/inward/record.url?scp=33644776867&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644776867&partnerID=8YFLogxK

U2 - 10.1111/j.1085-9489.2006.00063.x

DO - 10.1111/j.1085-9489.2006.00063.x

M3 - Article

VL - 11

SP - 53

EP - 60

JO - Journal of the Peripheral Nervous System

JF - Journal of the Peripheral Nervous System

SN - 1085-9489

IS - 1

ER -