Abstract
Fas/Apo-1 (CD95) is an apoptosis-signaling cell surface receptor belonging to the TNF receptor family. Tumor cells resistant to Fas-mediated apoptosis have been described, but to date, the mechanisms responsible for this resistance are not well understood. We found that a series of apoptosis- resistant clones from human HUT78 lymphoma cells express a splicing variant coding for a truncated Fas molecule that lacks the intracellular death- signaling domain. The mutation responsible for the FasExo8Del expression was identified as a deletion-insertion in the intron 7/exon 8 region of the Fas gene. Moreover this mutation affects the phenotype in a dominant negative fashion, i.e., even in the presence of the normal receptor.
Original language | English |
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Pages (from-to) | 13-17 |
Number of pages | 5 |
Journal | Journal of Immunology |
Volume | 156 |
Issue number | 1 |
Publication status | Published - Jan 1 1996 |
ASJC Scopus subject areas
- Immunology