Fascial preadipocytes: Another missing piece of the puzzle to understand fibromyalgia?

Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Francesca Cavallaro, David Lintonbon

Research output: Contribution to journalArticle

Abstract

Fibromyalgia (FM) syndrome is a chronic condition causing pain, affecting approximately 0.5%-6% of the developed countries’ population, and on average, 2% of the worldwide population. Despite the large amount of scientific literature available, the FM etiology is still uncertain. The diagnosis is based on the clinical presentation and the severity of the symptomatology. Several studies pointed out pathological alterations within the central nervous system, suggesting that FM could originate from a central sensitization of the pain processing centers. Research supports the thesis of a peripheral neuropathic component, with the finding of axonal damages. The fibromyalgia patient has many myofascial system abnormalities, such as pain and fatigue, impairing the symptomatic profile. This paper revises the myopathic compensations, highlighting the possible role of the fascia in generating symptoms, being aware of the new information about the fascia’s activity in stimulating inflammation and fat cell production.

Original languageEnglish
Pages (from-to)27-32
Number of pages6
JournalOpen Access Rheumatology: Research and Reviews
Volume10
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Fibromyalgia
Fascia
Central Nervous System Sensitization
Literature
Pain Clinics
Pain
Developed Countries
Adipocytes
Population
Fatigue
Central Nervous System
Inflammation
Research

Keywords

  • Fascia
  • Fibromyalgia
  • Myofascial
  • Neuropathic pain
  • Pain

ASJC Scopus subject areas

  • Rheumatology

Cite this

Fascial preadipocytes : Another missing piece of the puzzle to understand fibromyalgia? / Bordoni, Bruno; Marelli, Fabiola; Morabito, Bruno; Cavallaro, Francesca; Lintonbon, David.

In: Open Access Rheumatology: Research and Reviews, Vol. 10, 01.01.2018, p. 27-32.

Research output: Contribution to journalArticle

Bordoni, Bruno ; Marelli, Fabiola ; Morabito, Bruno ; Cavallaro, Francesca ; Lintonbon, David. / Fascial preadipocytes : Another missing piece of the puzzle to understand fibromyalgia?. In: Open Access Rheumatology: Research and Reviews. 2018 ; Vol. 10. pp. 27-32.
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