Fast potentiation of glycine receptor channels by intracellular calcium in neurons and transfected cells

Sergio Fucile, Didier De Saint Jan, Lia Prado De Carvalho, Piotr Bregestovski

Research output: Contribution to journalArticlepeer-review

Abstract

Inhibitory glycine receptors (GlyRs) are mainly expressed in the spinal cord and in the midbrain, where they control motor and sensory pathways. We describe here a fast potentiation of GlyR by intracellular Ca2+. This phenomenon was observed in rat spinal cord neurons and in transfected human cell lines. Potentiation develops in 2+ influx, and is characterized by an increase in GlyR apparent affinity for glycine. Phosphorylation and G protein pathways appear not to be involved in the potentiation mechanism. Single-channel recordings in cell-attached and excised patches, as well as whole-cell data suggest the presence of a diffusible cytoplasmic factor that modulates the GlyR channel gating properties. Ca2+-induced potentiation may be important for rapid modulation of glycinergic synapses.

Original languageEnglish
Pages (from-to)571-583
Number of pages13
JournalNeuron
Volume28
Issue number2
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Neuroscience(all)

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