Fastigial influences on postural tonus as studied by kainate lesions and by local infusion of GABAergic drugs in the rat

A. Imperato, F. Nicoletti, M. Diana, U. Scapagnini, G. Di Chiara

Research output: Contribution to journalArticle

Abstract

Localized lesions with kainic acid (KA) and local infusion of GABAergic drugs were used to study the role of the nucleus fastigii (NF) in postural tonus. Unilateral axon-sparing KA lesions of NF resulted in ipsilateral limb extensor atonia and contralateral limb extensor hypertonus and abduction. This effect lasted for 3-8 days depending on the dose of KA. Lesions of sites adjacent to the NF failed to produce postural asymmetries. Local infusion of the GABA agonist muscimol (10-50 ng) in the NF produced a reversible postural asymmetry fenomenologically similar to that produced by KA lesions of NF. Infusion of agents blocking GABAergic transmission in the NF (bicuculline, picrotoxin) resulted in a postural asymmetry of inverted laterality in respect to that produced by muscimol. Bilateral KA lesions of NF or bilateral infusion of muscimol resulted in bilateral hyperextension-abduction of the limbs. Infusion of GABAergic drugs in areas adjacent to the NF failed to produce postural changes. The results are interpreted to indicate that the NF exerts a crossed inhibitory and a direct excitatory influence on limb postural tonus.

Original languageEnglish
Pages (from-to)51-63
Number of pages13
JournalBrain Research
Volume295
Issue number1
DOIs
Publication statusPublished - Mar 12 1984

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Fastigial influences on postural tonus as studied by kainate lesions and by local infusion of GABAergic drugs in the rat'. Together they form a unique fingerprint.

  • Cite this