Fasting and post-methionine homocysteine levels in Alzheimer's disease and vascular dementia

Paola Villa, Paolo Bosco, Raffaele Ferri, Concetta Perri, Rosanna Suriano, Barbara Costantini, Francesca Macrì, Caterina Proto, Rosa Maria Cento, Antonio Lanzone

Research output: Contribution to journalArticlepeer-review


The aim of the study is to compare the basal homocysteine levels in patients with impairment of cognitive status, and in controls, to evaluate if the methionine loading test is able to identify any differences between patientswith Alzheimer's disease and patientswith vascular dementia.We enrolled 56 subjects, 20 with Alzheimer's disease, 18 with vascular dementia, and 18 normal controls. The data shown that plasma homocysteine levels both basal and post-methionine load were significantly higher in the two groups of demented patients than in the control group. No significant differences were found between Alzheimer's patients and vascular dementia patients. The homocysteine percent increase after a methionine loading test was significantly higher in the controls with respect to the two groups of demented patients. Only in Alzheimer's patients were vitamin B12 basal levels negatively correlated with basal homocysteine levels (p

Original languageEnglish
Pages (from-to)166-172
Number of pages7
JournalInternational Journal for Vitamin and Nutrition Research
Issue number3
Publication statusPublished - 2009


  • Alzheimer's
  • Cognitive deficit
  • Folate
  • Homocysteine
  • Methionine
  • Vascular dementia

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism


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