Fasting increases tobramycin oral absorption in mice

Luigina De Leo, Nicola Di Toro, Giuliana Decorti, Noelia Malusà, Alessandro Ventura, Tarcisio Not

Research output: Contribution to journalArticle

Abstract

The pharmacokinetics of the aminoglycoside tobramycin was evaluated after oral administration to fed or fasting (15 h) mice. As expected, under normal feeding conditions, oral absorption was negligible; however, fasting induced a dramatic increase in tobramycin bioavailability. The dual-sugar test with lactulose and L-rhamnose confirmed increased small bowel permeability via the paracellular route in fasting animals. When experiments aimed at increasing the oral bioavailability of hydrophilic compounds are performed, timing of fasting should be extremely accurate.

Original languageEnglish
Pages (from-to)1644-1646
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume54
Issue number4
DOIs
Publication statusPublished - Apr 2010

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ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

De Leo, L., Di Toro, N., Decorti, G., Malusà, N., Ventura, A., & Not, T. (2010). Fasting increases tobramycin oral absorption in mice. Antimicrobial Agents and Chemotherapy, 54(4), 1644-1646. https://doi.org/10.1128/AAC.01172-09