Abstract
The pharmacokinetics of the aminoglycoside tobramycin was evaluated after oral administration to fed or fasting (15 h) mice. As expected, under normal feeding conditions, oral absorption was negligible; however, fasting induced a dramatic increase in tobramycin bioavailability. The dual-sugar test with lactulose and L-rhamnose confirmed increased small bowel permeability via the paracellular route in fasting animals. When experiments aimed at increasing the oral bioavailability of hydrophilic compounds are performed, timing of fasting should be extremely accurate.
| Original language | English |
|---|---|
| Pages (from-to) | 1644-1646 |
| Number of pages | 3 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 54 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2010 |
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ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology
- Infectious Diseases
Cite this
Fasting increases tobramycin oral absorption in mice. / De Leo, Luigina; Di Toro, Nicola; Decorti, Giuliana; Malusà, Noelia; Ventura, Alessandro; Not, Tarcisio.
In: Antimicrobial Agents and Chemotherapy, Vol. 54, No. 4, 04.2010, p. 1644-1646.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fasting increases tobramycin oral absorption in mice
AU - De Leo, Luigina
AU - Di Toro, Nicola
AU - Decorti, Giuliana
AU - Malusà, Noelia
AU - Ventura, Alessandro
AU - Not, Tarcisio
PY - 2010/4
Y1 - 2010/4
N2 - The pharmacokinetics of the aminoglycoside tobramycin was evaluated after oral administration to fed or fasting (15 h) mice. As expected, under normal feeding conditions, oral absorption was negligible; however, fasting induced a dramatic increase in tobramycin bioavailability. The dual-sugar test with lactulose and L-rhamnose confirmed increased small bowel permeability via the paracellular route in fasting animals. When experiments aimed at increasing the oral bioavailability of hydrophilic compounds are performed, timing of fasting should be extremely accurate.
AB - The pharmacokinetics of the aminoglycoside tobramycin was evaluated after oral administration to fed or fasting (15 h) mice. As expected, under normal feeding conditions, oral absorption was negligible; however, fasting induced a dramatic increase in tobramycin bioavailability. The dual-sugar test with lactulose and L-rhamnose confirmed increased small bowel permeability via the paracellular route in fasting animals. When experiments aimed at increasing the oral bioavailability of hydrophilic compounds are performed, timing of fasting should be extremely accurate.
UR - http://www.scopus.com/inward/record.url?scp=77950108013&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950108013&partnerID=8YFLogxK
U2 - 10.1128/AAC.01172-09
DO - 10.1128/AAC.01172-09
M3 - Article
C2 - 20086144
AN - SCOPUS:77950108013
VL - 54
SP - 1644
EP - 1646
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 4
ER -