TY - JOUR
T1 - Fat mass and obesity-associated gene (FTO) in eating disorders
T2 - Evidence for association of the rs9939609 obesity risk allele with Bulimia nervosa and anorexia nervosa
AU - Müller, Timo D.
AU - Greene, Brandon H.
AU - Bellodi, Laura
AU - Cavallini, Maria C.
AU - Cellini, Elena
AU - Di Bella, Daniela
AU - Ehrlich, Stefan
AU - Erzegovesi, Stefano
AU - Estivill, Xavier
AU - Fernández-Aranda, Fernando
AU - Fichter, Manfred
AU - Fleischhaker, Christian
AU - Scherag, Susann
AU - Gratacòs, Monica
AU - Grallert, Harald
AU - Herpertz-Dahlmann, Beate
AU - Herzog, Wolfgang
AU - Illig, Thomas
AU - Lehmkuhl, Ulrike
AU - Nacmias, Benedetta
AU - Ribasés, Marta
AU - Ricca, Valdo
AU - Schäfer, Helmut
AU - Scherag, André
AU - Sorbi, Sandro
AU - Wichmann, Heinz Erich
AU - Hebebrand, Johannes
AU - Hinney, Anke
PY - 2012/6
Y1 - 2012/6
N2 - Objective: The common single nucleotide polymorphism (SNP) rs9939609 in the fat mass and obesity-associated gene (FTO) is associated with obesity. As genetic variants associated with weight regulation might also be implicated in the etiology of eating disorders, we evaluated whether SNP rs9939609 is associated with bulimia nervosa (BN) and anorexia nervosa (AN). Methods: Association of rs9939609 with BN and AN was assessed in 689 patients with AN, 477 patients with BN, 984 healthy non-population-based controls, and 3,951 population-based controls (KORA-S4). Based on the familial and premorbid occurrence of obesity in patients with BN, we hypothesized an association of the obesity risk A-allele with BN. Results: In accordance with our hypothesis, we observed evidence for association of the rs9939609 A-allele with BN when compared to the non-population-based controls (unadjusted odds ratio (OR) = 1.142, one-sided 95% confidence interval (CI) 1.001-∞; one-sided p = 0.049) and a trend in the population-based controls (OR = 1.124, one-sided 95% CI 0.932-∞; one-sided p = 0.056). Interestingly, compared to both control groups, we further detected a nominal association of the rs9939609 A-allele to AN (OR = 1.181, 95% CI 1.027-1.359, two-sided p = 0.020 or OR = 1.673, 95% CI 1.101-2.541, two-sided p = 0.015,). Conclusion: Our data suggest that the obesity-predisposing FTO allele might be relevant in both AN and BN.
AB - Objective: The common single nucleotide polymorphism (SNP) rs9939609 in the fat mass and obesity-associated gene (FTO) is associated with obesity. As genetic variants associated with weight regulation might also be implicated in the etiology of eating disorders, we evaluated whether SNP rs9939609 is associated with bulimia nervosa (BN) and anorexia nervosa (AN). Methods: Association of rs9939609 with BN and AN was assessed in 689 patients with AN, 477 patients with BN, 984 healthy non-population-based controls, and 3,951 population-based controls (KORA-S4). Based on the familial and premorbid occurrence of obesity in patients with BN, we hypothesized an association of the obesity risk A-allele with BN. Results: In accordance with our hypothesis, we observed evidence for association of the rs9939609 A-allele with BN when compared to the non-population-based controls (unadjusted odds ratio (OR) = 1.142, one-sided 95% confidence interval (CI) 1.001-∞; one-sided p = 0.049) and a trend in the population-based controls (OR = 1.124, one-sided 95% CI 0.932-∞; one-sided p = 0.056). Interestingly, compared to both control groups, we further detected a nominal association of the rs9939609 A-allele to AN (OR = 1.181, 95% CI 1.027-1.359, two-sided p = 0.020 or OR = 1.673, 95% CI 1.101-2.541, two-sided p = 0.015,). Conclusion: Our data suggest that the obesity-predisposing FTO allele might be relevant in both AN and BN.
KW - Anorexia nervosa
KW - Association study
KW - Bulimia nervosa
KW - Eating disorders
KW - Fat mass and obesity-associated gene
KW - FTO
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U2 - 10.1159/000340057
DO - 10.1159/000340057
M3 - Article
C2 - 22797368
AN - SCOPUS:84863979512
VL - 5
SP - 408
EP - 419
JO - Obesity Facts
JF - Obesity Facts
SN - 1662-4025
IS - 3
ER -