Fat mass and obesity-associated gene (FTO) in eating disorders: Evidence for association of the rs9939609 obesity risk allele with Bulimia nervosa and anorexia nervosa

Timo D. Müller, Brandon H. Greene, Laura Bellodi, Maria C. Cavallini, Elena Cellini, Daniela Di Bella, Stefan Ehrlich, Stefano Erzegovesi, Xavier Estivill, Fernando Fernández-Aranda, Manfred Fichter, Christian Fleischhaker, Susann Scherag, Monica Gratacòs, Harald Grallert, Beate Herpertz-Dahlmann, Wolfgang Herzog, Thomas Illig, Ulrike Lehmkuhl, Benedetta NacmiasMarta Ribasés, Valdo Ricca, Helmut Schäfer, André Scherag, Sandro Sorbi, Heinz Erich Wichmann, Johannes Hebebrand, Anke Hinney

Research output: Contribution to journalArticle

Abstract

Objective: The common single nucleotide polymorphism (SNP) rs9939609 in the fat mass and obesity-associated gene (FTO) is associated with obesity. As genetic variants associated with weight regulation might also be implicated in the etiology of eating disorders, we evaluated whether SNP rs9939609 is associated with bulimia nervosa (BN) and anorexia nervosa (AN). Methods: Association of rs9939609 with BN and AN was assessed in 689 patients with AN, 477 patients with BN, 984 healthy non-population-based controls, and 3,951 population-based controls (KORA-S4). Based on the familial and premorbid occurrence of obesity in patients with BN, we hypothesized an association of the obesity risk A-allele with BN. Results: In accordance with our hypothesis, we observed evidence for association of the rs9939609 A-allele with BN when compared to the non-population-based controls (unadjusted odds ratio (OR) = 1.142, one-sided 95% confidence interval (CI) 1.001-∞; one-sided p = 0.049) and a trend in the population-based controls (OR = 1.124, one-sided 95% CI 0.932-∞; one-sided p = 0.056). Interestingly, compared to both control groups, we further detected a nominal association of the rs9939609 A-allele to AN (OR = 1.181, 95% CI 1.027-1.359, two-sided p = 0.020 or OR = 1.673, 95% CI 1.101-2.541, two-sided p = 0.015,). Conclusion: Our data suggest that the obesity-predisposing FTO allele might be relevant in both AN and BN.

Original languageEnglish
Pages (from-to)408-419
Number of pages12
JournalObesity Facts
Volume5
Issue number3
DOIs
Publication statusPublished - Jun 2012

Keywords

  • Anorexia nervosa
  • Association study
  • Bulimia nervosa
  • Eating disorders
  • Fat mass and obesity-associated gene
  • FTO

ASJC Scopus subject areas

  • Physiology (medical)
  • Health(social science)

Fingerprint Dive into the research topics of 'Fat mass and obesity-associated gene (FTO) in eating disorders: Evidence for association of the rs9939609 obesity risk allele with Bulimia nervosa and anorexia nervosa'. Together they form a unique fingerprint.

  • Cite this

    Müller, T. D., Greene, B. H., Bellodi, L., Cavallini, M. C., Cellini, E., Di Bella, D., Ehrlich, S., Erzegovesi, S., Estivill, X., Fernández-Aranda, F., Fichter, M., Fleischhaker, C., Scherag, S., Gratacòs, M., Grallert, H., Herpertz-Dahlmann, B., Herzog, W., Illig, T., Lehmkuhl, U., ... Hinney, A. (2012). Fat mass and obesity-associated gene (FTO) in eating disorders: Evidence for association of the rs9939609 obesity risk allele with Bulimia nervosa and anorexia nervosa. Obesity Facts, 5(3), 408-419. https://doi.org/10.1159/000340057