Fatal cerebral haemorrhage after liver transplantation in a patient with transthyretin variant (gly53glu) amyloidosis

P. Carolis, M. Galeotti, G. Ficarra, M. Masetti, D. Grimaldi, P. Cortelli

Research output: Contribution to journalArticlepeer-review

Abstract

Transthyretin (TTR) amyloidosis is a form of systemic amyloidosis caused by an amyloidogenetic TTR variant. The most common mutant forms of TTR are mainly produced by the liver and therefore orthotopic liver transplantation (OLT) is currently accepted as the only known curative treatment. We describe the clinical and pathological features of a patient with TTR variant (gly53glu) with TTR amyloid infiltration of the leptomeningeal vessels in whom fatal cerebral haemorrhage occurred two months after OLT, soon after severe viral pneumonia.

Original languageEnglish
Pages (from-to)352-354
Number of pages3
JournalNeurological Sciences
Volume27
Issue number5
DOIs
Publication statusPublished - Nov 2006

Keywords

  • Cerebral haemorrhage
  • Liver transplantation
  • Transthyretin amyloidosis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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