Fatal involvement of the central nervous system in Langerhans cell histiocytosis

A. Di Cataldo, G. Bertuna, C. Gambini, L. Lo Nigro, M. La Spina, C. Maccagnano

Research output: Contribution to journalArticlepeer-review


We report the case of a child with Langerhans cell histiocytosis who experienced a minor response to treatment but then developed exophthalmus and seizures, and rapidly died. Magnetic resonance imaging showed signs suggestive of CNS involvement. These features suggested neurological progression of disease. Surveillance by MRI might help recognize and treat signs of neurological involvement when evolution is not so rapid.

Original languageEnglish
Pages (from-to)330-332
Number of pages3
JournalItalian Journal of Pediatrics
Issue number4
Publication statusPublished - Aug 2002


  • Central nervous system
  • Children
  • Langerhans cell histiocytosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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