Fatal necrotizing angiotropic epstein-barr virus-negative large B-cell lymphoma: A case report with unusual clinicopathological features in-between lymphomatoid granulomatosis and T-cell/histiocyte-rich large B-cell lymphoma

Attilio Olivieri, Elena Sabattini, Gaia Goteri, Silvia Trappolini, Francesco Saraceni, Arduino Samorì, Guido Gini, Pietro Leoni, Jacopo Olivieri, Stefano A. Pileri

Research output: Contribution to journalArticle

Abstract

In the spectrum of diffuse large B-cell lymphomas (DLBCL), both T-cell/histiocyte-rich large B-cell lymphoma (TCHRBCL) and most lymphomatoid granulomatosis (LG) cases are characterized by the relative rarity of the neoplastic B-cell population, with respect to the overwhelming non-neoplastic counterpart of T cells or histiocytes. Here we report a case of aggressive B-cell lymphoma with unusual clinicopathological features partially overlapping these two entities. The patient was a previously healthy 55-year-old male, presenting with a computed tomography finding of a pelvic mass, inguinal lymphadenopathies, and pulmonary nodules. Two excisional lymph node biopsies resulted inconclusive for lymphoproliferative disease. Because of a colonic perforation, the patient underwent an urgent laparotomy, which disclosed a large pelvic abscess. The pathological examination of the surgical specimen could not discriminate between a primary aggressive B-cell lymphoproliferative disorder and an abnormal inflammatory hyper-reaction. The patient developed a septic state, not resolving until death, which occurred because of an abdominal hemorrhage. A second perimortem surgical specimen consisting of a nodal mass revealed a diagnosis of an Epstein-Barr virus-negative high-grade large B-cell lymphoma with massive necrosis, angiocentric pattern of growth, and prominent T-cell infiltrate. The unique clinicopathological features did not allow to classify this tumor within any of the recognized WHO entities, potentially representing a new clinicopathological variant of DLBCL in-between TCHRBCL and LG.

Original languageEnglish
Pages (from-to)e353
JournalMedicine (United States)
Volume93
Issue number29
DOIs
Publication statusPublished - Dec 13 2014

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Lymphomatoid Granulomatosis
Histiocytes
B-Cell Lymphoma
Human Herpesvirus 4
T-Lymphocytes
B-Lymphocytes
T-Cell Lymphoma
Lymphoproliferative Disorders
Lymphoma, Large B-Cell, Diffuse
Groin
Laparotomy
Abscess
Necrosis
Lymph Nodes
Tomography
Hemorrhage
Biopsy
Lung
Growth
Population

ASJC Scopus subject areas

  • Medicine(all)

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Fatal necrotizing angiotropic epstein-barr virus-negative large B-cell lymphoma : A case report with unusual clinicopathological features in-between lymphomatoid granulomatosis and T-cell/histiocyte-rich large B-cell lymphoma. / Olivieri, Attilio; Sabattini, Elena; Goteri, Gaia; Trappolini, Silvia; Saraceni, Francesco; Samorì, Arduino; Gini, Guido; Leoni, Pietro; Olivieri, Jacopo; Pileri, Stefano A.

In: Medicine (United States), Vol. 93, No. 29, 13.12.2014, p. e353.

Research output: Contribution to journalArticle

Olivieri, Attilio ; Sabattini, Elena ; Goteri, Gaia ; Trappolini, Silvia ; Saraceni, Francesco ; Samorì, Arduino ; Gini, Guido ; Leoni, Pietro ; Olivieri, Jacopo ; Pileri, Stefano A. / Fatal necrotizing angiotropic epstein-barr virus-negative large B-cell lymphoma : A case report with unusual clinicopathological features in-between lymphomatoid granulomatosis and T-cell/histiocyte-rich large B-cell lymphoma. In: Medicine (United States). 2014 ; Vol. 93, No. 29. pp. e353.
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