Fatal pulmonary infection due to multidrug-resistant Mycobacterium abscessus in a patient with cystic fibrosis

M. Sanguinetti, F. Ardito, E. Fiscarelli, M. La Sorda, P. D'Argenio, G. Ricciotti, G. Fadda

Research output: Contribution to journalArticlepeer-review

Abstract

We report a case of fatal pulmonary infection caused by Mycobacterium abscessus in a young patient with cystic fibrosis, who underwent bipulmonary transplantation after a 1-year history of severe lung disease. Fifteen days after surgery he developed septic fever with progressive deterioration in lung function. M. abscessus, initially isolated from a pleural fluid specimen, was then recovered from repeated blood samples, suggesting a disseminated nature of the mycobacterial disease. Drug susceptibility testing assay, performed on two sequential isolates of the microorganism, showed a pattern of multidrug resistance. Despite aggressive therapy with several antimycobacterial drugs, including clarithromycin, the infection persisted, and the patient died.

Original languageEnglish
Pages (from-to)816-819
Number of pages4
JournalJournal of Clinical Microbiology
Volume39
Issue number2
DOIs
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Fingerprint Dive into the research topics of 'Fatal pulmonary infection due to multidrug-resistant Mycobacterium abscessus in a patient with cystic fibrosis'. Together they form a unique fingerprint.

Cite this