Fate of PLA and PCL-Based Polymeric Nanocarriers in Cellular and Animal Models of Triple-Negative Breast Cancer

Leopoldo Sitia, Raffaele Ferrari, Martina B. Violatto, Laura Talamini, Luca Dragoni, Claudio Colombo, Laura Colombo, Monica Lupi, Paolo Ubezio, Maurizio D'Incalci, Massimo Morbidelli, Mario Salmona, Davide Moscatelli, Paolo Bigini

Research output: Contribution to journalArticle

Abstract

An integrated platform to assess the interaction between nanocarriers and biological matrices has been developed by our group using poly methyl-methacrylate nanoparticles. In this study, we exploited this platform to evaluate the behavior of two biodegradable formulations, poly-ε-caprolactone (PCL3) and poly lactic-acid (PLA8), respectively, in cellular and animal models of triple-negative breast cancer (TNBC). Both NPs shared the main physicochemical parameters (size, shape, ζ-potential) and exclusively differentiated on the material on which they are composed. Our results showed that (1) PLA8 NPs, systemically injected in mice, underwent rapid degradation without penetration into tumors; (2) PLA8 NPs were not internalized in the human TNBC cell line (MDA-MB-231); (3) PCL3 NPs had a longer bioavailability, reached the tumor parenchyma, and efficiently penetrated in MDA-MB-231 cells. Our data highlight the relevance of the material selection to both improve bioavailability and target tropism, and make PCL3 NPs an interesting tool for the development of nanodrugs against TNBC.

Original languageEnglish
Pages (from-to)744-755
Number of pages12
JournalBiomacromolecules
Volume17
Issue number3
DOIs
Publication statusPublished - Mar 14 2016

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ASJC Scopus subject areas

  • Bioengineering
  • Materials Chemistry
  • Polymers and Plastics
  • Biomaterials

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