Fatigue in Multiple Sclerosis is associated with abnormal cortical activation to voluntary movement - EEG evidence

Letizia Leocani, Bruno Colombo, Giuseppe Magnani, Filippo Martinelli-Boneschi, Marco Cursi, Paolo Rossi, Vittorio Martinelli, Giancarlo Comi

Research output: Contribution to journalArticle

Abstract

Converging evidence is consistent with the view that fatigue in Multiple Sclerosis is independent from pyramidal tract involvement, suggesting a possible involvement of frontal areas. During voluntary movement, changes of the EEG rhythms can be observed over sensorimotor areas. Event-related desynchronization (ERD) of the 10 and 20 Hz frequency bands occurs during motor planning and execution and is followed after movement termination by event-related synchronization (ERS), expressing cortical idling or inhibition. We evaluated the pattern of cortical activation to voluntary movement in MS patients complaining of fatigue assessed using the Fatigue Severity Scale. Fifteen MS patients complaining of fatigue, 18 MS patients without fatigue, and 14 normal controls were studied. The two patients groups were similar for age, sex, disease duration, and were not disabled (score

Original languageEnglish
Pages (from-to)1186-1192
Number of pages7
JournalNeuroImage
Volume13
Issue number6
DOIs
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

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