Fatigue strength of PMMA bone cement mixed with gentamicin and barium sulphate vs pure PMMA

M. Baleani, L. Cristofolini, C. Minari, A. Toni

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Barium sulphate is added to polymethylmethacrylate (PMMA) bone cement as a radio-pacifier. Gentamicin is an antibiotic added to bone cement to treat or prevent infection in arthroplasty. This study investigated the combined effect of barium sulphate and gentamicin sulphate on the fatigue strength of PMMA bone cement. Three different formulations were studied: pure PMMA, PMMA with barium sulphate added and PMMA with barium sulphate and gentamicin sulphate added. Before testing all specimens were stored in water at 37°C for at least 15 days to season the PMMA and to elute the antibiotic. Fatigue tests were performed following a previously validated procedure. The slope part of the Wöhler diagram was obtained and a rough endurance limit was estimated for all three formulations. The experimental data showed that the addition of barium sulphate to PMMA bone cement affected the fatigue strength of the material, whereas addition of gentamicin sulphate to the radiopaque PMMA had no effect on the fatigue properties of the bone cement. While PMMA with barium sulphate added was confirmed to have a reduced fatigue strength when compared with plain PMMA, no detrimental effect was found for the addition of gentamicin sulphate to radiopaque PMMA.

Original languageEnglish
Pages (from-to)9-12
Number of pages4
JournalProceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine
Volume217
Issue number1
DOIs
Publication statusPublished - 2003

Fingerprint

Barium Sulfate
Bone cement
Bone Cements
Polymethyl Methacrylate
Barium
Gentamicins
Fatigue
Antibiotics
Fatigue strength
Sulfates
Fatigue of materials
Pacifiers
Arthroplasty
Anti-Bacterial Agents
Radio
Durability

Keywords

  • Additives
  • Antibiotic
  • Barium sulphate
  • Bone cement
  • Fatigue

ASJC Scopus subject areas

  • Biomedical Engineering
  • Mechanical Engineering
  • Medicine(all)

Cite this

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abstract = "Barium sulphate is added to polymethylmethacrylate (PMMA) bone cement as a radio-pacifier. Gentamicin is an antibiotic added to bone cement to treat or prevent infection in arthroplasty. This study investigated the combined effect of barium sulphate and gentamicin sulphate on the fatigue strength of PMMA bone cement. Three different formulations were studied: pure PMMA, PMMA with barium sulphate added and PMMA with barium sulphate and gentamicin sulphate added. Before testing all specimens were stored in water at 37°C for at least 15 days to season the PMMA and to elute the antibiotic. Fatigue tests were performed following a previously validated procedure. The slope part of the W{\"o}hler diagram was obtained and a rough endurance limit was estimated for all three formulations. The experimental data showed that the addition of barium sulphate to PMMA bone cement affected the fatigue strength of the material, whereas addition of gentamicin sulphate to the radiopaque PMMA had no effect on the fatigue properties of the bone cement. While PMMA with barium sulphate added was confirmed to have a reduced fatigue strength when compared with plain PMMA, no detrimental effect was found for the addition of gentamicin sulphate to radiopaque PMMA.",
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AU - Cristofolini, L.

AU - Minari, C.

AU - Toni, A.

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AB - Barium sulphate is added to polymethylmethacrylate (PMMA) bone cement as a radio-pacifier. Gentamicin is an antibiotic added to bone cement to treat or prevent infection in arthroplasty. This study investigated the combined effect of barium sulphate and gentamicin sulphate on the fatigue strength of PMMA bone cement. Three different formulations were studied: pure PMMA, PMMA with barium sulphate added and PMMA with barium sulphate and gentamicin sulphate added. Before testing all specimens were stored in water at 37°C for at least 15 days to season the PMMA and to elute the antibiotic. Fatigue tests were performed following a previously validated procedure. The slope part of the Wöhler diagram was obtained and a rough endurance limit was estimated for all three formulations. The experimental data showed that the addition of barium sulphate to PMMA bone cement affected the fatigue strength of the material, whereas addition of gentamicin sulphate to the radiopaque PMMA had no effect on the fatigue properties of the bone cement. While PMMA with barium sulphate added was confirmed to have a reduced fatigue strength when compared with plain PMMA, no detrimental effect was found for the addition of gentamicin sulphate to radiopaque PMMA.

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