Fatty acid synthase expression in Paget's disease of the vulva

Piero Luigi Alo, Gregorio M. Galati, Valeria Sebastiani, Francesca Ricci, Paolo Visca, Luciano Mariani, Francesca Romagnoli, Giuseppe Lombardi, Ugo Di Tondo

Research output: Contribution to journalArticlepeer-review


We explored the immunohistochemical expression of fatty acid synthase (FAS) in Paget's disease of the vulva (PDV) and its association with clinico-pathological features. FAS is a recently discovered molecule involved in energy supply of normal cells. FAS is also overexpressed in neoplastic tissues because of their increased necessity of energy. Specimens from 20 patients with PDV were immunohistochemically evaluated; increased FAS expression was observed in 7 of 8 patients with invasive PDV (87%), in 3 of 4 patients with microinvasive PDV (75%), and in 1 of 8 patients with noninvasive PDV (12%). Statistical analysis revealed that increased FAS expression was associated with invasive PDV (p = 0.04). To our knowledge, this association of FAS in PDV is the first to be reported in literature. These observations reveal that FAS is a reliable marker of aggressiveness in PDV. The knowledge of FAS statistical association in invasive PDV is an important finding that may stratify these patients in different prognostic groups and determine therapeutic approaches for patient care.

Original languageEnglish
Pages (from-to)404-408
Number of pages5
JournalInternational Journal of Gynecological Pathology
Issue number4
Publication statusPublished - Oct 2005


  • Fatty acid synthase
  • Paget
  • Vulva

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynaecology


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