Four patients with idiopathic myelofibrosis showed a fatty bone marrow with severe myeloid hypoplasia at the iliac crest. The quantitation of erythropoiesis by ferrokinetics demonstrated a great increase of total erythropoiesis (more than five times the normal) with high degrees of ineffectiveness and the absence of erythropoiesis over the sacrum. The spleen and liver were the only sites exhibiting quantitable erythropoiesis. This severe bone marrow hypoplasia was interpreted as an early tendency to transfer axial hemopoiesis to peripheral sites of bone marrow or to extramedullary sites. This rare anatomic-functional entity presents with some diagnostic difficulties and the follow up of one case suggests to be prudent in therapeutic approaches aimed at reducing splenic myelopoiesis.
|Number of pages||5|
|Publication status||Published - 1986|
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