Favorable association of polyphenol-rich diets with lung function

Cross-sectional findings from the Moli-sani study

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: The association of the polyphenol content of human diet with pulmonary function is not yet fully understood. This study aims at evaluating the association of polyphenol consumption with lung function in a novel holistic approach. Methods: A cross-sectional analysis of 4551 women and 5108 men (age ≥35 years) from the Moli-sani study was performed. Participants were randomly recruited from the general population. The EPIC-FFQ was used for the dietary assessment. Polyphenol intakes were calculated using Eurofir–eBASIS, and a polyphenol antioxidant content (PAC) score was constructed to assess the total content of the diet in these nutrients. Pulmonary function maneuvers were performed, and the forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1) were measured; FVC% predicted and FEV1% predicted were computed using the European Community of Coal and Steel prediction equations that included height and age. Results: In both genders, in age, height, and energy intake adjusted models, the majority of classes of polyphenols (mg/day) showed a positive association with FEV1, FVC, FEV1% predicted, and FVC% predicted (β-coef >0, P <.05). Associations remained significant after adjustment for confounding factors in most cases (β-coef >0, P <.05). The PAC score was associated in both genders with an increase in pulmonary function parameters (β-coef >0, P <.05). The inclusion of white blood cell (WBC) counts in the multivariate model reduced the association in men but not in women.. Conclusions: A higher overall polyphenol content of human diet was associated with better pulmonary function in a general population. The association might be partially mediated by WBC in men.

Original languageEnglish
Pages (from-to)48-57
Number of pages10
JournalRespiratory Medicine
Volume136
DOIs
Publication statusPublished - Mar 1 2018

Fingerprint

Polyphenols
Vital Capacity
Diet
Lung
Forced Expiratory Volume
European Union
Energy Intake
Leukocyte Count
Population
Leukocytes
Cross-Sectional Studies
Antioxidants
Food

Keywords

  • Forced expiratory volume in the first second
  • Forced vital capacity
  • Inflammation
  • Oxidative stress
  • Polyphenols
  • Pulmonary function

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

@article{634a12b68a584c0ba59f3be54601559e,
title = "Favorable association of polyphenol-rich diets with lung function: Cross-sectional findings from the Moli-sani study",
abstract = "Background: The association of the polyphenol content of human diet with pulmonary function is not yet fully understood. This study aims at evaluating the association of polyphenol consumption with lung function in a novel holistic approach. Methods: A cross-sectional analysis of 4551 women and 5108 men (age ≥35 years) from the Moli-sani study was performed. Participants were randomly recruited from the general population. The EPIC-FFQ was used for the dietary assessment. Polyphenol intakes were calculated using Eurofir–eBASIS, and a polyphenol antioxidant content (PAC) score was constructed to assess the total content of the diet in these nutrients. Pulmonary function maneuvers were performed, and the forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1) were measured; FVC{\%} predicted and FEV1{\%} predicted were computed using the European Community of Coal and Steel prediction equations that included height and age. Results: In both genders, in age, height, and energy intake adjusted models, the majority of classes of polyphenols (mg/day) showed a positive association with FEV1, FVC, FEV1{\%} predicted, and FVC{\%} predicted (β-coef >0, P <.05). Associations remained significant after adjustment for confounding factors in most cases (β-coef >0, P <.05). The PAC score was associated in both genders with an increase in pulmonary function parameters (β-coef >0, P <.05). The inclusion of white blood cell (WBC) counts in the multivariate model reduced the association in men but not in women.. Conclusions: A higher overall polyphenol content of human diet was associated with better pulmonary function in a general population. The association might be partially mediated by WBC in men.",
keywords = "Forced expiratory volume in the first second, Forced vital capacity, Inflammation, Oxidative stress, Polyphenols, Pulmonary function",
author = "George Pounis and Antonella Arcari and Simona Costanzo and {Di Castelnuovo}, Augusto and Marialaura Bonaccio and Mariarosaria Persichillo and Donati, {Maria Benedetta} and {de Gaetano}, Giovanni and Licia Iacoviello",
year = "2018",
month = "3",
day = "1",
doi = "10.1016/j.rmed.2017.12.007",
language = "English",
volume = "136",
pages = "48--57",
journal = "Respiratory Medicine",
issn = "0954-6111",
publisher = "W.B. Saunders Ltd",

}

TY - JOUR

T1 - Favorable association of polyphenol-rich diets with lung function

T2 - Cross-sectional findings from the Moli-sani study

AU - Pounis, George

AU - Arcari, Antonella

AU - Costanzo, Simona

AU - Di Castelnuovo, Augusto

AU - Bonaccio, Marialaura

AU - Persichillo, Mariarosaria

AU - Donati, Maria Benedetta

AU - de Gaetano, Giovanni

AU - Iacoviello, Licia

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Background: The association of the polyphenol content of human diet with pulmonary function is not yet fully understood. This study aims at evaluating the association of polyphenol consumption with lung function in a novel holistic approach. Methods: A cross-sectional analysis of 4551 women and 5108 men (age ≥35 years) from the Moli-sani study was performed. Participants were randomly recruited from the general population. The EPIC-FFQ was used for the dietary assessment. Polyphenol intakes were calculated using Eurofir–eBASIS, and a polyphenol antioxidant content (PAC) score was constructed to assess the total content of the diet in these nutrients. Pulmonary function maneuvers were performed, and the forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1) were measured; FVC% predicted and FEV1% predicted were computed using the European Community of Coal and Steel prediction equations that included height and age. Results: In both genders, in age, height, and energy intake adjusted models, the majority of classes of polyphenols (mg/day) showed a positive association with FEV1, FVC, FEV1% predicted, and FVC% predicted (β-coef >0, P <.05). Associations remained significant after adjustment for confounding factors in most cases (β-coef >0, P <.05). The PAC score was associated in both genders with an increase in pulmonary function parameters (β-coef >0, P <.05). The inclusion of white blood cell (WBC) counts in the multivariate model reduced the association in men but not in women.. Conclusions: A higher overall polyphenol content of human diet was associated with better pulmonary function in a general population. The association might be partially mediated by WBC in men.

AB - Background: The association of the polyphenol content of human diet with pulmonary function is not yet fully understood. This study aims at evaluating the association of polyphenol consumption with lung function in a novel holistic approach. Methods: A cross-sectional analysis of 4551 women and 5108 men (age ≥35 years) from the Moli-sani study was performed. Participants were randomly recruited from the general population. The EPIC-FFQ was used for the dietary assessment. Polyphenol intakes were calculated using Eurofir–eBASIS, and a polyphenol antioxidant content (PAC) score was constructed to assess the total content of the diet in these nutrients. Pulmonary function maneuvers were performed, and the forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1) were measured; FVC% predicted and FEV1% predicted were computed using the European Community of Coal and Steel prediction equations that included height and age. Results: In both genders, in age, height, and energy intake adjusted models, the majority of classes of polyphenols (mg/day) showed a positive association with FEV1, FVC, FEV1% predicted, and FVC% predicted (β-coef >0, P <.05). Associations remained significant after adjustment for confounding factors in most cases (β-coef >0, P <.05). The PAC score was associated in both genders with an increase in pulmonary function parameters (β-coef >0, P <.05). The inclusion of white blood cell (WBC) counts in the multivariate model reduced the association in men but not in women.. Conclusions: A higher overall polyphenol content of human diet was associated with better pulmonary function in a general population. The association might be partially mediated by WBC in men.

KW - Forced expiratory volume in the first second

KW - Forced vital capacity

KW - Inflammation

KW - Oxidative stress

KW - Polyphenols

KW - Pulmonary function

UR - http://www.scopus.com/inward/record.url?scp=85041382160&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041382160&partnerID=8YFLogxK

U2 - 10.1016/j.rmed.2017.12.007

DO - 10.1016/j.rmed.2017.12.007

M3 - Article

VL - 136

SP - 48

EP - 57

JO - Respiratory Medicine

JF - Respiratory Medicine

SN - 0954-6111

ER -