Abstract
Background: The association of the polyphenol content of human diet with pulmonary function is not yet fully understood. This study aims at evaluating the association of polyphenol consumption with lung function in a novel holistic approach. Methods: A cross-sectional analysis of 4551 women and 5108 men (age ≥35 years) from the Moli-sani study was performed. Participants were randomly recruited from the general population. The EPIC-FFQ was used for the dietary assessment. Polyphenol intakes were calculated using Eurofir–eBASIS, and a polyphenol antioxidant content (PAC) score was constructed to assess the total content of the diet in these nutrients. Pulmonary function maneuvers were performed, and the forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1) were measured; FVC% predicted and FEV1% predicted were computed using the European Community of Coal and Steel prediction equations that included height and age. Results: In both genders, in age, height, and energy intake adjusted models, the majority of classes of polyphenols (mg/day) showed a positive association with FEV1, FVC, FEV1% predicted, and FVC% predicted (β-coef >0, P <.05). Associations remained significant after adjustment for confounding factors in most cases (β-coef >0, P <.05). The PAC score was associated in both genders with an increase in pulmonary function parameters (β-coef >0, P <.05). The inclusion of white blood cell (WBC) counts in the multivariate model reduced the association in men but not in women.. Conclusions: A higher overall polyphenol content of human diet was associated with better pulmonary function in a general population. The association might be partially mediated by WBC in men.
| Original language | English |
|---|---|
| Pages (from-to) | 48-57 |
| Number of pages | 10 |
| Journal | Respiratory Medicine |
| Volume | 136 |
| DOIs | |
| Publication status | Published - Mar 1 2018 |
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Keywords
- Forced expiratory volume in the first second
- Forced vital capacity
- Inflammation
- Oxidative stress
- Polyphenols
- Pulmonary function
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Favorable association of polyphenol-rich diets with lung function : Cross-sectional findings from the Moli-sani study. / Pounis, George; Arcari, Antonella; Costanzo, Simona; Di Castelnuovo, Augusto; Bonaccio, Marialaura; Persichillo, Mariarosaria; Donati, Maria Benedetta; de Gaetano, Giovanni; Iacoviello, Licia.
In: Respiratory Medicine, Vol. 136, 01.03.2018, p. 48-57.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Favorable association of polyphenol-rich diets with lung function
T2 - Cross-sectional findings from the Moli-sani study
AU - Pounis, George
AU - Arcari, Antonella
AU - Costanzo, Simona
AU - Di Castelnuovo, Augusto
AU - Bonaccio, Marialaura
AU - Persichillo, Mariarosaria
AU - Donati, Maria Benedetta
AU - de Gaetano, Giovanni
AU - Iacoviello, Licia
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Background: The association of the polyphenol content of human diet with pulmonary function is not yet fully understood. This study aims at evaluating the association of polyphenol consumption with lung function in a novel holistic approach. Methods: A cross-sectional analysis of 4551 women and 5108 men (age ≥35 years) from the Moli-sani study was performed. Participants were randomly recruited from the general population. The EPIC-FFQ was used for the dietary assessment. Polyphenol intakes were calculated using Eurofir–eBASIS, and a polyphenol antioxidant content (PAC) score was constructed to assess the total content of the diet in these nutrients. Pulmonary function maneuvers were performed, and the forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1) were measured; FVC% predicted and FEV1% predicted were computed using the European Community of Coal and Steel prediction equations that included height and age. Results: In both genders, in age, height, and energy intake adjusted models, the majority of classes of polyphenols (mg/day) showed a positive association with FEV1, FVC, FEV1% predicted, and FVC% predicted (β-coef >0, P <.05). Associations remained significant after adjustment for confounding factors in most cases (β-coef >0, P <.05). The PAC score was associated in both genders with an increase in pulmonary function parameters (β-coef >0, P <.05). The inclusion of white blood cell (WBC) counts in the multivariate model reduced the association in men but not in women.. Conclusions: A higher overall polyphenol content of human diet was associated with better pulmonary function in a general population. The association might be partially mediated by WBC in men.
AB - Background: The association of the polyphenol content of human diet with pulmonary function is not yet fully understood. This study aims at evaluating the association of polyphenol consumption with lung function in a novel holistic approach. Methods: A cross-sectional analysis of 4551 women and 5108 men (age ≥35 years) from the Moli-sani study was performed. Participants were randomly recruited from the general population. The EPIC-FFQ was used for the dietary assessment. Polyphenol intakes were calculated using Eurofir–eBASIS, and a polyphenol antioxidant content (PAC) score was constructed to assess the total content of the diet in these nutrients. Pulmonary function maneuvers were performed, and the forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1) were measured; FVC% predicted and FEV1% predicted were computed using the European Community of Coal and Steel prediction equations that included height and age. Results: In both genders, in age, height, and energy intake adjusted models, the majority of classes of polyphenols (mg/day) showed a positive association with FEV1, FVC, FEV1% predicted, and FVC% predicted (β-coef >0, P <.05). Associations remained significant after adjustment for confounding factors in most cases (β-coef >0, P <.05). The PAC score was associated in both genders with an increase in pulmonary function parameters (β-coef >0, P <.05). The inclusion of white blood cell (WBC) counts in the multivariate model reduced the association in men but not in women.. Conclusions: A higher overall polyphenol content of human diet was associated with better pulmonary function in a general population. The association might be partially mediated by WBC in men.
KW - Forced expiratory volume in the first second
KW - Forced vital capacity
KW - Inflammation
KW - Oxidative stress
KW - Polyphenols
KW - Pulmonary function
UR - http://www.scopus.com/inward/record.url?scp=85041382160&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041382160&partnerID=8YFLogxK
U2 - 10.1016/j.rmed.2017.12.007
DO - 10.1016/j.rmed.2017.12.007
M3 - Article
C2 - 29501246
AN - SCOPUS:85041382160
VL - 136
SP - 48
EP - 57
JO - Respiratory Medicine
JF - Respiratory Medicine
SN - 0954-6111
ER -