Favorable Changes in Fasting Glucose in a 6-month Self-Monitored Lifestyle Modification Programme Inversely Affects Spexin Levels in Females with Prediabetes

Nasser M. Al-Daghri, Kaiser Wani, Sobhy M. Yakout, Hazim Al-Hazmi, Osama E. Amer, Syed Danish Hussain, Shaun Sabico, Mohammed Ghouse Ahmed Ansari, Sara Al-Musharaf, Amal M. Alenad, Majed S. Alokail, Mario Clerici

Research output: Contribution to journalArticle

Abstract

Spexin (SPX) is a novel peptide thought to have a role in various metabolic regulations. Given its presumed body-weight regulatory functions, we aimed to determine whether lifestyle intervention programs on weight loss and fasting glucose (FG) improvement among people with impaired glucose regulation also alter levels of circulating SPX. A total of 160 Saudi adult males and females with prediabetes were randomly selected from a larger cohort (N = 294) who underwent a 6-month lifestyle modification program to improve their glycemic status. Participants were split into two groups based on differences in glucose levels post-intervention, with the first 50% (improved group) having the most significant reduction in FG. SPX was measured at baseline and after 6 months. Changes in SPX was significant only in the improved group [baseline: median (Q1–Q3) of 164 pg/ml (136–227) vs follow-up: 176 pg/ml (146–285); p < 0.01]. When stratified by sex, the significant increase was observed only in females [159 pg/ml (127–252) vs 182.5 (152,369.1); p < 0.01]. Furthermore, SPX levels showed a significant inverse association with FG (β = −0.22, p = 0.003) even after adjustment with age and BMI, again only in females. Circulating SPX levels increase over time in people with prediabetes, particularly women who responded favorably in a 6-month lifestyle intervention program. Whether an unknown mechanism regulating the sexual disparity seen in SPX levels post-intervention exists should be further investigated using a larger sample size.

Original languageEnglish
Article number9454
JournalScientific Reports
Volume9
Issue number1
DOIs
Publication statusPublished - Dec 1 2019

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Prediabetic State
Life Style
Fasting
Glucose
Weight Reduction Programs
Social Adjustment
Sample Size
Body Weight
Peptides

ASJC Scopus subject areas

  • General

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Favorable Changes in Fasting Glucose in a 6-month Self-Monitored Lifestyle Modification Programme Inversely Affects Spexin Levels in Females with Prediabetes. / Al-Daghri, Nasser M.; Wani, Kaiser; Yakout, Sobhy M.; Al-Hazmi, Hazim; Amer, Osama E.; Hussain, Syed Danish; Sabico, Shaun; Ansari, Mohammed Ghouse Ahmed; Al-Musharaf, Sara; Alenad, Amal M.; Alokail, Majed S.; Clerici, Mario.

In: Scientific Reports, Vol. 9, No. 1, 9454, 01.12.2019.

Research output: Contribution to journalArticle

Al-Daghri, NM, Wani, K, Yakout, SM, Al-Hazmi, H, Amer, OE, Hussain, SD, Sabico, S, Ansari, MGA, Al-Musharaf, S, Alenad, AM, Alokail, MS & Clerici, M 2019, 'Favorable Changes in Fasting Glucose in a 6-month Self-Monitored Lifestyle Modification Programme Inversely Affects Spexin Levels in Females with Prediabetes', Scientific Reports, vol. 9, no. 1, 9454. https://doi.org/10.1038/s41598-019-46006-0
Al-Daghri, Nasser M. ; Wani, Kaiser ; Yakout, Sobhy M. ; Al-Hazmi, Hazim ; Amer, Osama E. ; Hussain, Syed Danish ; Sabico, Shaun ; Ansari, Mohammed Ghouse Ahmed ; Al-Musharaf, Sara ; Alenad, Amal M. ; Alokail, Majed S. ; Clerici, Mario. / Favorable Changes in Fasting Glucose in a 6-month Self-Monitored Lifestyle Modification Programme Inversely Affects Spexin Levels in Females with Prediabetes. In: Scientific Reports. 2019 ; Vol. 9, No. 1.
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abstract = "Spexin (SPX) is a novel peptide thought to have a role in various metabolic regulations. Given its presumed body-weight regulatory functions, we aimed to determine whether lifestyle intervention programs on weight loss and fasting glucose (FG) improvement among people with impaired glucose regulation also alter levels of circulating SPX. A total of 160 Saudi adult males and females with prediabetes were randomly selected from a larger cohort (N = 294) who underwent a 6-month lifestyle modification program to improve their glycemic status. Participants were split into two groups based on differences in glucose levels post-intervention, with the first 50{\%} (improved group) having the most significant reduction in FG. SPX was measured at baseline and after 6 months. Changes in SPX was significant only in the improved group [baseline: median (Q1–Q3) of 164 pg/ml (136–227) vs follow-up: 176 pg/ml (146–285); p < 0.01]. When stratified by sex, the significant increase was observed only in females [159 pg/ml (127–252) vs 182.5 (152,369.1); p < 0.01]. Furthermore, SPX levels showed a significant inverse association with FG (β = −0.22, p = 0.003) even after adjustment with age and BMI, again only in females. Circulating SPX levels increase over time in people with prediabetes, particularly women who responded favorably in a 6-month lifestyle intervention program. Whether an unknown mechanism regulating the sexual disparity seen in SPX levels post-intervention exists should be further investigated using a larger sample size.",
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AU - Al-Hazmi, Hazim

AU - Amer, Osama E.

AU - Hussain, Syed Danish

AU - Sabico, Shaun

AU - Ansari, Mohammed Ghouse Ahmed

AU - Al-Musharaf, Sara

AU - Alenad, Amal M.

AU - Alokail, Majed S.

AU - Clerici, Mario

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