Abstract
Background: Left atrial enlargement is an important predictor of cardiovascular outcomes in patients after acute myocardial infarction. While the favourable effect of exercise exercise-based Cardiac Rehabilitation (CR) on postinfarction LV remodeling has been well documented, those on LA remodeling have yet to be defined. This study investigated the effects of CR on LA remodeling in postinfarction patients with moderate left ventricular (LV) dysfunction. Methods: Sixty postinfarction patients were randomised randomized into two groups, each composed of 30 patients: group T (LV ejection fraction (EF) 43.7 ± 4.2%, mean ± SD) entered a 6-month CR program, whereas group C (EF 44.7 ± 4.4%, P = ns) did not. Doppler echocardiography and cardiopulmonary exercise test were performed upon enrolment and at 6-month. Results: At 6-month, trained patients showed a significant (P <0.001) improvement in peak oxygen consumption (ΔVO2peak = + 5.2 ± 2.1 ml/kg/min) and a reduction in LA (ΔLAVMAX = - 1.9 ± 3.7 ml/m2) and in LV volumes (ΔLVEDV = - 3.6 ± 4.4 ml/m2). At 6-month, untrained patients showed LAVMAX (+ 3.6 ± 4.4 ml/m2, P <0.001) and LV dilation (+ 4.2 ± 5.1 ml/m2, P <0.001; group T vs. C, P <0.001); whereas no significant changes in VO2peak were observed. Multiple linear regression analysis showed that age (β = 0.442, P <0.001), inclusion in the training group (β = - 0.599, P <0.001), E/A ratio (β = - 0.210, P = 0.038), LVEDV (β = 0.376, P <0.001), and LVEF (β = - 0.279, P = 0.007) are significant predictors of LA remodeling. Conclusions: Six-month exercise-based CR in postinfarction patients with mild to moderate LV dysfunction induced a favourable LA remodeling.
| Original language | English |
|---|---|
| Pages (from-to) | 300-306 |
| Number of pages | 7 |
| Journal | International Journal of Cardiology |
| Volume | 136 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Aug 21 2009 |
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Keywords
- Acute myocardial infarction
- Cardiac rehabilitation
- Cardiopulmonary exercise test
- Cardiopulmonary functional capacity
- Exercise training
- Left atrial remodeling
- Left ventricular remodeling
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Favourable effects of exercise-based Cardiac Rehabilitation after acute myocardial infarction on left atrial remodeling. / Giallauria, Francesco; Galizia, Gianluigi; Lucci, Rosa; D'Agostino, Mariantonietta; Vitelli, Alessandra; Maresca, Luigi; Orio, Francesco; Vigorito, Carlo.
In: International Journal of Cardiology, Vol. 136, No. 3, 21.08.2009, p. 300-306.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Favourable effects of exercise-based Cardiac Rehabilitation after acute myocardial infarction on left atrial remodeling
AU - Giallauria, Francesco
AU - Galizia, Gianluigi
AU - Lucci, Rosa
AU - D'Agostino, Mariantonietta
AU - Vitelli, Alessandra
AU - Maresca, Luigi
AU - Orio, Francesco
AU - Vigorito, Carlo
PY - 2009/8/21
Y1 - 2009/8/21
N2 - Background: Left atrial enlargement is an important predictor of cardiovascular outcomes in patients after acute myocardial infarction. While the favourable effect of exercise exercise-based Cardiac Rehabilitation (CR) on postinfarction LV remodeling has been well documented, those on LA remodeling have yet to be defined. This study investigated the effects of CR on LA remodeling in postinfarction patients with moderate left ventricular (LV) dysfunction. Methods: Sixty postinfarction patients were randomised randomized into two groups, each composed of 30 patients: group T (LV ejection fraction (EF) 43.7 ± 4.2%, mean ± SD) entered a 6-month CR program, whereas group C (EF 44.7 ± 4.4%, P = ns) did not. Doppler echocardiography and cardiopulmonary exercise test were performed upon enrolment and at 6-month. Results: At 6-month, trained patients showed a significant (P <0.001) improvement in peak oxygen consumption (ΔVO2peak = + 5.2 ± 2.1 ml/kg/min) and a reduction in LA (ΔLAVMAX = - 1.9 ± 3.7 ml/m2) and in LV volumes (ΔLVEDV = - 3.6 ± 4.4 ml/m2). At 6-month, untrained patients showed LAVMAX (+ 3.6 ± 4.4 ml/m2, P <0.001) and LV dilation (+ 4.2 ± 5.1 ml/m2, P <0.001; group T vs. C, P <0.001); whereas no significant changes in VO2peak were observed. Multiple linear regression analysis showed that age (β = 0.442, P <0.001), inclusion in the training group (β = - 0.599, P <0.001), E/A ratio (β = - 0.210, P = 0.038), LVEDV (β = 0.376, P <0.001), and LVEF (β = - 0.279, P = 0.007) are significant predictors of LA remodeling. Conclusions: Six-month exercise-based CR in postinfarction patients with mild to moderate LV dysfunction induced a favourable LA remodeling.
AB - Background: Left atrial enlargement is an important predictor of cardiovascular outcomes in patients after acute myocardial infarction. While the favourable effect of exercise exercise-based Cardiac Rehabilitation (CR) on postinfarction LV remodeling has been well documented, those on LA remodeling have yet to be defined. This study investigated the effects of CR on LA remodeling in postinfarction patients with moderate left ventricular (LV) dysfunction. Methods: Sixty postinfarction patients were randomised randomized into two groups, each composed of 30 patients: group T (LV ejection fraction (EF) 43.7 ± 4.2%, mean ± SD) entered a 6-month CR program, whereas group C (EF 44.7 ± 4.4%, P = ns) did not. Doppler echocardiography and cardiopulmonary exercise test were performed upon enrolment and at 6-month. Results: At 6-month, trained patients showed a significant (P <0.001) improvement in peak oxygen consumption (ΔVO2peak = + 5.2 ± 2.1 ml/kg/min) and a reduction in LA (ΔLAVMAX = - 1.9 ± 3.7 ml/m2) and in LV volumes (ΔLVEDV = - 3.6 ± 4.4 ml/m2). At 6-month, untrained patients showed LAVMAX (+ 3.6 ± 4.4 ml/m2, P <0.001) and LV dilation (+ 4.2 ± 5.1 ml/m2, P <0.001; group T vs. C, P <0.001); whereas no significant changes in VO2peak were observed. Multiple linear regression analysis showed that age (β = 0.442, P <0.001), inclusion in the training group (β = - 0.599, P <0.001), E/A ratio (β = - 0.210, P = 0.038), LVEDV (β = 0.376, P <0.001), and LVEF (β = - 0.279, P = 0.007) are significant predictors of LA remodeling. Conclusions: Six-month exercise-based CR in postinfarction patients with mild to moderate LV dysfunction induced a favourable LA remodeling.
KW - Acute myocardial infarction
KW - Cardiac rehabilitation
KW - Cardiopulmonary exercise test
KW - Cardiopulmonary functional capacity
KW - Exercise training
KW - Left atrial remodeling
KW - Left ventricular remodeling
UR - http://www.scopus.com/inward/record.url?scp=68049087664&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=68049087664&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2008.05.026
DO - 10.1016/j.ijcard.2008.05.026
M3 - Article
C2 - 18676038
AN - SCOPUS:68049087664
VL - 136
SP - 300
EP - 306
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
IS - 3
ER -