Favourable evolution of virological and immunological profiles in treated and untreated patients in Italy in the period 1998-2008

M. C F Prosperi, A. Cozzi-Lepri, A. Antinori, G. Cassola, C. Torti, M. A. Ursitti, G. P. Pellizzer, A. Giacometti, A. D'Arminio Monforte, A. De Luca

Research output: Contribution to journalArticlepeer-review

Abstract

Background: This study provides an estimate of the proportion of HIV-positive patients in Italian clinics showing an 'adverse prognosis' (defined as a CD4 count ≤200cells/μL or an HIV RNA >50 HIV-1 RNA copies/mL) over time, and investigates whether this proportion varied according to patients' characteristics. Methods: We estimated the annual proportion of patients with a CD4 count ≤200cells/μL or HIV RNA >50copies/mL out of the total number of patients in the Icona Foundation cohort seen in any given year, both overall and after stratifying by demographical and treatment status groups. Generalized estimating equation models for Poisson regression were applied. Results: In 1998-2008, the prevalence of patients with a CD4 count ≤200cells/μL decreased from 14 to 6% [adjusted relative risk (RR) 0.86/year; 95% confidence interval (CI) 0.84-0.88; P50copies/mL decreased from 66 to 40% (adjusted RR 0.95/year; 95% CI 0.95-0.96; P

Original languageEnglish
Pages (from-to)174-182
Number of pages9
JournalHIV Medicine
Volume12
Issue number3
DOIs
Publication statusPublished - Mar 2011

Keywords

  • HIV-1
  • Immunological response rates
  • Poisson regression
  • Virological response rates

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)
  • Health Policy

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