Abstract
Background: This study provides an estimate of the proportion of HIV-positive patients in Italian clinics showing an 'adverse prognosis' (defined as a CD4 count ≤200cells/μL or an HIV RNA >50 HIV-1 RNA copies/mL) over time, and investigates whether this proportion varied according to patients' characteristics. Methods: We estimated the annual proportion of patients with a CD4 count ≤200cells/μL or HIV RNA >50copies/mL out of the total number of patients in the Icona Foundation cohort seen in any given year, both overall and after stratifying by demographical and treatment status groups. Generalized estimating equation models for Poisson regression were applied. Results: In 1998-2008, the prevalence of patients with a CD4 count ≤200cells/μL decreased from 14 to 6% [adjusted relative risk (RR) 0.86/year; 95% confidence interval (CI) 0.84-0.88; P50copies/mL decreased from 66 to 40% (adjusted RR 0.95/year; 95% CI 0.95-0.96; P
Original language | English |
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Pages (from-to) | 174-182 |
Number of pages | 9 |
Journal | HIV Medicine |
Volume | 12 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 2011 |
Keywords
- HIV-1
- Immunological response rates
- Poisson regression
- Virological response rates
ASJC Scopus subject areas
- Infectious Diseases
- Pharmacology (medical)
- Health Policy