Fcγ receptor IIA genotype and susceptibility to P. aeruginosa infection in patients with cystic fibrosis

Virginia De Rose, Carlo Arduino, Nazario Cappello, Rita Piana, Paola Salmin, Marco Bardessono, Manuela Goia, Rita Padoan, Elisabetta Bignamini, Diana Costantini, Giovanna Pizzamiglio, Veronica Bennato, Carla Colombo, Anna Maria Giunta, Alberto Piazza

Research output: Contribution to journalArticlepeer-review

Abstract

It has been suggested that genes other than CFTR could modulate the severity of lung disease in cystic fibrosis (CF). Neutrophil Fcγ receptor II (FcγRII) is involved in host defense against microorganisms and in inflammatory response. We evaluated the association between genetic variability of this gene and both airway infection with Pseudomonas aeruginosa and severity of lung disease in patients with CF. We studied 167 Italian unrelated patients with CF and 50 control subjects. The distribution of FcγRIIA genotypes in CF patients was compared with that in control subjects and the different genotypes were related with the presence or absence of P. aeruginosa infection and markers of disease severity in CF patients. The distribution of FcγRIIA genotypes was not significantly different between CF patients and controls. We observed that in CF patients with the same CFTR genotype (ΔF508/ΔF508), those carrying the R allele of FcγRIIA had an increased risk of acquiring chronic P. aeruginosa infection (P=0.042, R.R.: 4.38; 95% CI: 1.17 ÷ 22.4). Moreover, the frequency of R/R genotype in patients with chronic P. aeruginosa infection seems to be higher than that of control subjects and patients without chronic infection. The observation that CF patients carrying the R allele of FcγRIIA are at higher risk of acquiring chronic P. aeruginosa infection suggests that the FcγRII loci genetic variation is contributing to this infection susceptibility.

Original languageEnglish
Pages (from-to)96-101
Number of pages6
JournalEuropean Journal of Human Genetics
Volume13
Issue number1
DOIs
Publication statusPublished - Jan 2005

Keywords

  • Cystic fibrosis
  • Fcγ receptor II
  • Infection
  • P. aeruginosa

ASJC Scopus subject areas

  • Genetics(clinical)

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