FcγRIII discriminates between 2 subsets of Vγ9Vδ2 effector cells with different responses and activation pathways

Daniela F. Angelini, Giovanna Borsellino, Mary Poupot, Adamo Diamantini, Rémy Poupot, Giorgio Bernardi, Fabrizio Poccia, Jean Jacques Fournié, Luca Battistini

Research output: Contribution to journalArticle

Abstract

Upon recognition of nonpeptidic phosphoantigens, human Vδ2 T lymphocytes enter a lineage differentiation pattern that determines the generation of memory cells with a range of effector functions. Here, we show that within the effector memory Vδ2 population, 2 distinct and complementary subsets with regard to phenotype, mode of activation, and type of responses can be identified: Vδ2 TEMh cells, which express high levels of chemokine receptors, but low levels of perform and of natural killer receptors (NKRs) and which produce large amounts of interferon γ(IFN-γ) and tumor necrosis factor α (TNF-α) in response to T-cell receptor (TCR)-specific stimulation by phosphoantigens; and Vδ2 TEMRA cells, which constitutively express several NKRs, high amounts of perform, but low levels of chemokine receptors and of IFN-γ. These NK-like cells are refractory to phosphoantigen but respond to activation via FcγRIII (CD16) and are highly active against tumoral target cells. Thus, circulating Vδ2 T lymphocytes comprise 2 functionally diverse subsets of effector memory cells that may be discriminated on the basis of CD16 expression.

Original languageEnglish
Pages (from-to)1801-1807
Number of pages7
JournalBlood
Volume104
Issue number6
DOIs
Publication statusPublished - Sep 15 2004

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ASJC Scopus subject areas

  • Hematology

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