Concanavalin A (Con A) stimulated the IgM-binding subpopulation of human T cells (T(M)) to suppress the pokeweed mitogen-induced differentiation of B lymphocytes to plasma cells. Control T(M) cells that had not been Con A activated did not suppress. The degree of suppression was related to the number of Con A-T(M) cells added to the cultures and it was abolished by irradiation of the T lymphocytes either before or after the 24-hr culture period with Con A. Suppression did not require the presence of T(M) cells, whose suppressor potential has been previously established. These findings indicate that suppressor activity is not confined to the T(M) subpopulation but may be expressed by T(M) cells also.
|Number of pages||5|
|Journal||Journal of Immunology|
|Publication status||Published - 1978|
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