Fc receptor triggering induces expression of surface activation antigens and release of platelet-activating factor in large granular lymphocytes

F. Malavasi; C. Tetta; A. Funaro; G. Bellone; E. Ferrero; A. C. Franzone; P. Dellabona; R. Rusci; L. Matera; G. Camussi

Fc receptor triggering induces expression of surface activation antigens and release of platelet-activating factor in large granular lymphocytes

F. Malavasi, C. Tetta, A. Funaro, G. Bellone, E. Ferrero, A. C. Franzone, P. Dellabona, R. Rusci, L. Matera, G. Camussi

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Triggering of large granular lymphocyte (LGL) Fc receptor with a specific monoclonal antibody (AB8.28) linked to an insoluble matrix induces cell activation, as witnessed by expression of HLA class II (DR and DQ) molecules and interleukin 2 receptor. Moreover, this event is accompanied by a concomitant release of platelet-activating factor by LGL. We conclude that the Fc receptor molecule identified by mAb AB8.28 represents a trigger for LGL activation.

Original language	English
Pages (from-to)	2443-2447
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	83
Issue number	8
Publication status	Published - 1986

ASJC Scopus subject areas

Genetics
General

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Malavasi, F., Tetta, C., Funaro, A., Bellone, G., Ferrero, E., Franzone, A. C., Dellabona, P., Rusci, R., Matera, L., & Camussi, G. (1986). Fc receptor triggering induces expression of surface activation antigens and release of platelet-activating factor in large granular lymphocytes. Proceedings of the National Academy of Sciences of the United States of America, 83(8), 2443-2447.

Fc receptor triggering induces expression of surface activation antigens and release of platelet-activating factor in large granular lymphocytes. / Malavasi, F.; Tetta, C.; Funaro, A. et al.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, No. 8, 1986, p. 2443-2447.

Research output: Contribution to journal › Article › peer-review

Malavasi, F, Tetta, C, Funaro, A, Bellone, G, Ferrero, E, Franzone, AC, Dellabona, P, Rusci, R, Matera, L & Camussi, G 1986, 'Fc receptor triggering induces expression of surface activation antigens and release of platelet-activating factor in large granular lymphocytes', Proceedings of the National Academy of Sciences of the United States of America, vol. 83, no. 8, pp. 2443-2447.

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abstract = "Triggering of large granular lymphocyte (LGL) Fc receptor with a specific monoclonal antibody (AB8.28) linked to an insoluble matrix induces cell activation, as witnessed by expression of HLA class II (DR and DQ) molecules and interleukin 2 receptor. Moreover, this event is accompanied by a concomitant release of platelet-activating factor by LGL. We conclude that the Fc receptor molecule identified by mAb AB8.28 represents a trigger for LGL activation.",

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AU - Malavasi, F.

AU - Tetta, C.

AU - Funaro, A.

AU - Bellone, G.

AU - Ferrero, E.

AU - Franzone, A. C.

AU - Dellabona, P.

AU - Rusci, R.

AU - Matera, L.

AU - Camussi, G.

PY - 1986

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N2 - Triggering of large granular lymphocyte (LGL) Fc receptor with a specific monoclonal antibody (AB8.28) linked to an insoluble matrix induces cell activation, as witnessed by expression of HLA class II (DR and DQ) molecules and interleukin 2 receptor. Moreover, this event is accompanied by a concomitant release of platelet-activating factor by LGL. We conclude that the Fc receptor molecule identified by mAb AB8.28 represents a trigger for LGL activation.

AB - Triggering of large granular lymphocyte (LGL) Fc receptor with a specific monoclonal antibody (AB8.28) linked to an insoluble matrix induces cell activation, as witnessed by expression of HLA class II (DR and DQ) molecules and interleukin 2 receptor. Moreover, this event is accompanied by a concomitant release of platelet-activating factor by LGL. We conclude that the Fc receptor molecule identified by mAb AB8.28 represents a trigger for LGL activation.

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JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 8

ER -

Fc receptor triggering induces expression of surface activation antigens and release of platelet-activating factor in large granular lymphocytes

Abstract

ASJC Scopus subject areas

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