Fc receptor triggering induces expression of surface activation antigens and release of platelet-activating factor in large granular lymphocytes

F. Malavasi, C. Tetta, A. Funaro, G. Bellone, E. Ferrero, A. C. Franzone, P. Dellabona, R. Rusci, L. Matera, G. Camussi

Research output: Contribution to journalArticle

Abstract

Triggering of large granular lymphocyte (LGL) Fc receptor with a specific monoclonal antibody (AB8.28) linked to an insoluble matrix induces cell activation, as witnessed by expression of HLA class II (DR and DQ) molecules and interleukin 2 receptor. Moreover, this event is accompanied by a concomitant release of platelet-activating factor by LGL. We conclude that the Fc receptor molecule identified by mAb AB8.28 represents a trigger for LGL activation.

Original languageEnglish
Pages (from-to)2443-2447
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume83
Issue number8
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Genetics
  • General

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