Abstract
Triggering of large granular lymphocyte (LGL) Fc receptor with a specific monoclonal antibody (AB8.28) linked to an insoluble matrix induces cell activation, as witnessed by expression of HLA class II (DR and DQ) molecules and interleukin 2 receptor. Moreover, this event is accompanied by a concomitant release of platelet-activating factor by LGL. We conclude that the Fc receptor molecule identified by mAb AB8.28 represents a trigger for LGL activation.
| Original language | English |
|---|---|
| Pages (from-to) | 2443-2447 |
| Number of pages | 5 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 83 |
| Issue number | 8 |
| Publication status | Published - 1986 |
ASJC Scopus subject areas
- Genetics
- General
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Malavasi, F., Tetta, C., Funaro, A., Bellone, G., Ferrero, E., Franzone, A. C., Dellabona, P., Rusci, R., Matera, L., & Camussi, G. (1986). Fc receptor triggering induces expression of surface activation antigens and release of platelet-activating factor in large granular lymphocytes. Proceedings of the National Academy of Sciences of the United States of America, 83(8), 2443-2447.