Fc receptors on human T lymphocytes: Loss of Fcμ and expression of Fcγ receptors by T cells stimulated in mixed lymphocyte reaction

A. Moretta, M. C. Mingari, M. Colombatti, L. Moretta

Research output: Contribution to journalArticle

Abstract

The consequences of allogeneic stimulation on the expression of Fcμ or Fcγ receptors were analysed in T-cell populations responding in mixed lymphocyte reaction (MLR). Unfractionated T-cell populations were cultured with a pool of irradiated allogeneic T-depleted cells. The responder E-rosetting cells progressively lost Fcμ and acquired Fcγ receptor. The change of the original Fc receptor phenotype is not the consequence of a preferential proliferative response of T(G) versus T(M) cells but is likely due to a de novo expression of Fcγ receptor by T cells lacking detectable Fc receptors (T-null) and also to the loss of Fcμ and expression of Fcγ receptors by T(M) cells. These data suggest that, after MLR, responder T cells can modify their Fc receptor phenotype.

Original languageEnglish
Pages (from-to)447-451
Number of pages5
JournalScandinavian Journal of Immunology
Volume13
Issue number5
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Immunology

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