FDG PET-derived parameters as prognostic tool in progressive malignant pleural mesothelioma treated patients

E Incerti, S Broggi, A Fodor, M Cuzzocrea, AM Samanes Gajate, P Mapelli, C Fiorino, I Dell’Oca, M Pasetti, M Cattaneo, R Calandrino, L Gianolli, N Di Muzio, M Picchio

Research output: Contribution to journalArticle

Abstract

Purpose: The value of FDG PET-derived parameters in predicting overall survival (OS), local relapse-free survival (LRFS) and distant relapse-free survival (DRFS) in treated patients with malignant pleural mesothelioma (MPM) was evaluated. Methods: This retrospective evaluation included 55 MPM patients treated between March 2006 and February 2015 with FDG PET/CT-guided salvage helical tomotherapy (HTT) after previous surgery plus chemotherapy. Univariate Cox regression analysis was performed to assess the impact of the following FDG PET-derived parameters: biological target volume (BTV), mean and maximum standardized uptake values (SUVmean/max), metabolic tumour volume (MTV) and total lesion glycolysis (TLG), measured using different uptake thresholds (40%, 50% and 60%). Logistic regression was then performed to identify the best FDG PET-derived parameters for selecting patients with poorer survival. Results: The median OS was 9.1 months (range 0.0 – 69.6 months) after the end of HTT; 54/55 patients were dead at the last follow-up. BTV and TLG40, TLG50 and TLG60 were the most significant predictors of OS (p <0.005). The median OS was 4.8 months in patients with MTV60 >5 cm3and TLG40 >334.4, compared with 13.8 months and 16.1 months in patients with smaller values, respectively. The median LRFS and DRFS were 6.2 months (range 1.2 – 39.4 months) and 6.5 months (0.0 – 66.4 months), respectively. TLG40, TLG50 and TLG60 were significantly correlated with LRFS (p <0.015). Median DRFS was 6.4 months in patients with MTV40 >39.6 cm3and 6.2 months in patients with TLG40 >334.4, compared with 17 months and 18.8 months in patients with smaller values. BTV, TLG40 and MTV40 were also found to be good predictors in patients with poor OS/LRFS/DRFS (median survival times less than the median values). Conclusion: FDG PET-derived parameters effectively discriminated patients with a poor prognosis and may be helpful in the selection of MPM patients for salvage HTT. © 2018 Springer-Verlag GmbH Germany, part of Springer Nature
Original languageEnglish
Pages (from-to)2071-2078
Number of pages8
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume45
Issue number12
DOIs
Publication statusPublished - 2018

Fingerprint

Survival
Recurrence
Intensity-Modulated Radiotherapy
Malignant Mesothelioma
Glycolysis
Tumor Burden
Germany
Logistic Models
Regression Analysis
Drug Therapy

Cite this

FDG PET-derived parameters as prognostic tool in progressive malignant pleural mesothelioma treated patients. / Incerti, E; Broggi, S; Fodor, A; Cuzzocrea, M; Samanes Gajate, AM; Mapelli, P; Fiorino, C; Dell’Oca, I; Pasetti, M; Cattaneo, M; Calandrino, R; Gianolli, L; Di Muzio, N; Picchio, M.

In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 45, No. 12, 2018, p. 2071-2078.

Research output: Contribution to journalArticle

Incerti, E ; Broggi, S ; Fodor, A ; Cuzzocrea, M ; Samanes Gajate, AM ; Mapelli, P ; Fiorino, C ; Dell’Oca, I ; Pasetti, M ; Cattaneo, M ; Calandrino, R ; Gianolli, L ; Di Muzio, N ; Picchio, M. / FDG PET-derived parameters as prognostic tool in progressive malignant pleural mesothelioma treated patients. In: European Journal of Nuclear Medicine and Molecular Imaging. 2018 ; Vol. 45, No. 12. pp. 2071-2078.
@article{bae2fbd4486f403c9ab263f3dc9f75f9,
title = "FDG PET-derived parameters as prognostic tool in progressive malignant pleural mesothelioma treated patients",
abstract = "Purpose: The value of FDG PET-derived parameters in predicting overall survival (OS), local relapse-free survival (LRFS) and distant relapse-free survival (DRFS) in treated patients with malignant pleural mesothelioma (MPM) was evaluated. Methods: This retrospective evaluation included 55 MPM patients treated between March 2006 and February 2015 with FDG PET/CT-guided salvage helical tomotherapy (HTT) after previous surgery plus chemotherapy. Univariate Cox regression analysis was performed to assess the impact of the following FDG PET-derived parameters: biological target volume (BTV), mean and maximum standardized uptake values (SUVmean/max), metabolic tumour volume (MTV) and total lesion glycolysis (TLG), measured using different uptake thresholds (40{\%}, 50{\%} and 60{\%}). Logistic regression was then performed to identify the best FDG PET-derived parameters for selecting patients with poorer survival. Results: The median OS was 9.1 months (range 0.0 – 69.6 months) after the end of HTT; 54/55 patients were dead at the last follow-up. BTV and TLG40, TLG50 and TLG60 were the most significant predictors of OS (p <0.005). The median OS was 4.8 months in patients with MTV60 >5 cm3and TLG40 >334.4, compared with 13.8 months and 16.1 months in patients with smaller values, respectively. The median LRFS and DRFS were 6.2 months (range 1.2 – 39.4 months) and 6.5 months (0.0 – 66.4 months), respectively. TLG40, TLG50 and TLG60 were significantly correlated with LRFS (p <0.015). Median DRFS was 6.4 months in patients with MTV40 >39.6 cm3and 6.2 months in patients with TLG40 >334.4, compared with 17 months and 18.8 months in patients with smaller values. BTV, TLG40 and MTV40 were also found to be good predictors in patients with poor OS/LRFS/DRFS (median survival times less than the median values). Conclusion: FDG PET-derived parameters effectively discriminated patients with a poor prognosis and may be helpful in the selection of MPM patients for salvage HTT. {\circledC} 2018 Springer-Verlag GmbH Germany, part of Springer Nature",
author = "E Incerti and S Broggi and A Fodor and M Cuzzocrea and {Samanes Gajate}, AM and P Mapelli and C Fiorino and I Dell’Oca and M Pasetti and M Cattaneo and R Calandrino and L Gianolli and {Di Muzio}, N and M Picchio",
year = "2018",
doi = "10.1007/s00259-018-4056-6",
language = "English",
volume = "45",
pages = "2071--2078",
journal = "European Journal of Nuclear Medicine and Molecular Imaging",
issn = "1619-7070",
publisher = "Springer Verlag",
number = "12",

}

TY - JOUR

T1 - FDG PET-derived parameters as prognostic tool in progressive malignant pleural mesothelioma treated patients

AU - Incerti, E

AU - Broggi, S

AU - Fodor, A

AU - Cuzzocrea, M

AU - Samanes Gajate, AM

AU - Mapelli, P

AU - Fiorino, C

AU - Dell’Oca, I

AU - Pasetti, M

AU - Cattaneo, M

AU - Calandrino, R

AU - Gianolli, L

AU - Di Muzio, N

AU - Picchio, M

PY - 2018

Y1 - 2018

N2 - Purpose: The value of FDG PET-derived parameters in predicting overall survival (OS), local relapse-free survival (LRFS) and distant relapse-free survival (DRFS) in treated patients with malignant pleural mesothelioma (MPM) was evaluated. Methods: This retrospective evaluation included 55 MPM patients treated between March 2006 and February 2015 with FDG PET/CT-guided salvage helical tomotherapy (HTT) after previous surgery plus chemotherapy. Univariate Cox regression analysis was performed to assess the impact of the following FDG PET-derived parameters: biological target volume (BTV), mean and maximum standardized uptake values (SUVmean/max), metabolic tumour volume (MTV) and total lesion glycolysis (TLG), measured using different uptake thresholds (40%, 50% and 60%). Logistic regression was then performed to identify the best FDG PET-derived parameters for selecting patients with poorer survival. Results: The median OS was 9.1 months (range 0.0 – 69.6 months) after the end of HTT; 54/55 patients were dead at the last follow-up. BTV and TLG40, TLG50 and TLG60 were the most significant predictors of OS (p <0.005). The median OS was 4.8 months in patients with MTV60 >5 cm3and TLG40 >334.4, compared with 13.8 months and 16.1 months in patients with smaller values, respectively. The median LRFS and DRFS were 6.2 months (range 1.2 – 39.4 months) and 6.5 months (0.0 – 66.4 months), respectively. TLG40, TLG50 and TLG60 were significantly correlated with LRFS (p <0.015). Median DRFS was 6.4 months in patients with MTV40 >39.6 cm3and 6.2 months in patients with TLG40 >334.4, compared with 17 months and 18.8 months in patients with smaller values. BTV, TLG40 and MTV40 were also found to be good predictors in patients with poor OS/LRFS/DRFS (median survival times less than the median values). Conclusion: FDG PET-derived parameters effectively discriminated patients with a poor prognosis and may be helpful in the selection of MPM patients for salvage HTT. © 2018 Springer-Verlag GmbH Germany, part of Springer Nature

AB - Purpose: The value of FDG PET-derived parameters in predicting overall survival (OS), local relapse-free survival (LRFS) and distant relapse-free survival (DRFS) in treated patients with malignant pleural mesothelioma (MPM) was evaluated. Methods: This retrospective evaluation included 55 MPM patients treated between March 2006 and February 2015 with FDG PET/CT-guided salvage helical tomotherapy (HTT) after previous surgery plus chemotherapy. Univariate Cox regression analysis was performed to assess the impact of the following FDG PET-derived parameters: biological target volume (BTV), mean and maximum standardized uptake values (SUVmean/max), metabolic tumour volume (MTV) and total lesion glycolysis (TLG), measured using different uptake thresholds (40%, 50% and 60%). Logistic regression was then performed to identify the best FDG PET-derived parameters for selecting patients with poorer survival. Results: The median OS was 9.1 months (range 0.0 – 69.6 months) after the end of HTT; 54/55 patients were dead at the last follow-up. BTV and TLG40, TLG50 and TLG60 were the most significant predictors of OS (p <0.005). The median OS was 4.8 months in patients with MTV60 >5 cm3and TLG40 >334.4, compared with 13.8 months and 16.1 months in patients with smaller values, respectively. The median LRFS and DRFS were 6.2 months (range 1.2 – 39.4 months) and 6.5 months (0.0 – 66.4 months), respectively. TLG40, TLG50 and TLG60 were significantly correlated with LRFS (p <0.015). Median DRFS was 6.4 months in patients with MTV40 >39.6 cm3and 6.2 months in patients with TLG40 >334.4, compared with 17 months and 18.8 months in patients with smaller values. BTV, TLG40 and MTV40 were also found to be good predictors in patients with poor OS/LRFS/DRFS (median survival times less than the median values). Conclusion: FDG PET-derived parameters effectively discriminated patients with a poor prognosis and may be helpful in the selection of MPM patients for salvage HTT. © 2018 Springer-Verlag GmbH Germany, part of Springer Nature

U2 - 10.1007/s00259-018-4056-6

DO - 10.1007/s00259-018-4056-6

M3 - Article

VL - 45

SP - 2071

EP - 2078

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

SN - 1619-7070

IS - 12

ER -