Abstract
Purpose: To characterise tissue sites of immune activation and HIV replication we performed FDG-PET in ART-treated and ART-naive HIV-infected individuals. Specific aims were to establish whether HIV-infected patients can be differentiated on the basis of the detection of specific locations of viral replication, even in the presence of an apparently optimal immunovirological response to ART, and whether these FDG-PET findings can be related to immunovirological variables and AIDS history status. Patients and methods: Patients were divided into five groups as follows: subgroup A1 (full responders, n∈=∈8): current ART treatment, CD4+ T lymphocytes >500/mL, viral load 50,000 copies/mL; group C (ART-naïve, n∈=∈5): no current or previous ART treatment, increased viral load. Results: PET images revealed different patterns of FDG uptake. All ART-treated patients with either suppressed (
| Original language | English |
|---|---|
| Pages (from-to) | 640-647 |
| Number of pages | 8 |
| Journal | European Journal of Nuclear Medicine and Molecular Imaging |
| Volume | 36 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2009 |
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Keywords
- F-2-fluoro-2-deoxy-d-glucose
- ART
- FDG-PET
- HIV
- Imaging
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
FDG-PET imaging in HIV-infected subjects : Relation with therapy and immunovirological variables. / Lucignani, Giovanni; Orunesu, Eva; Cesari, Miriam; Marzo, Katia; Pacei, Michela; Bechi, Giulia; Gori, Andrea; Gaito, Sabrina; Clerici, Mario; Chiti, Arturo.
In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 36, No. 4, 04.2009, p. 640-647.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - FDG-PET imaging in HIV-infected subjects
T2 - Relation with therapy and immunovirological variables
AU - Lucignani, Giovanni
AU - Orunesu, Eva
AU - Cesari, Miriam
AU - Marzo, Katia
AU - Pacei, Michela
AU - Bechi, Giulia
AU - Gori, Andrea
AU - Gaito, Sabrina
AU - Clerici, Mario
AU - Chiti, Arturo
PY - 2009/4
Y1 - 2009/4
N2 - Purpose: To characterise tissue sites of immune activation and HIV replication we performed FDG-PET in ART-treated and ART-naive HIV-infected individuals. Specific aims were to establish whether HIV-infected patients can be differentiated on the basis of the detection of specific locations of viral replication, even in the presence of an apparently optimal immunovirological response to ART, and whether these FDG-PET findings can be related to immunovirological variables and AIDS history status. Patients and methods: Patients were divided into five groups as follows: subgroup A1 (full responders, n∈=∈8): current ART treatment, CD4+ T lymphocytes >500/mL, viral load 50,000 copies/mL; group C (ART-naïve, n∈=∈5): no current or previous ART treatment, increased viral load. Results: PET images revealed different patterns of FDG uptake. All ART-treated patients with either suppressed (
AB - Purpose: To characterise tissue sites of immune activation and HIV replication we performed FDG-PET in ART-treated and ART-naive HIV-infected individuals. Specific aims were to establish whether HIV-infected patients can be differentiated on the basis of the detection of specific locations of viral replication, even in the presence of an apparently optimal immunovirological response to ART, and whether these FDG-PET findings can be related to immunovirological variables and AIDS history status. Patients and methods: Patients were divided into five groups as follows: subgroup A1 (full responders, n∈=∈8): current ART treatment, CD4+ T lymphocytes >500/mL, viral load 50,000 copies/mL; group C (ART-naïve, n∈=∈5): no current or previous ART treatment, increased viral load. Results: PET images revealed different patterns of FDG uptake. All ART-treated patients with either suppressed (
KW - F-2-fluoro-2-deoxy-d-glucose
KW - ART
KW - FDG-PET
KW - HIV
KW - Imaging
UR - http://www.scopus.com/inward/record.url?scp=62149145795&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=62149145795&partnerID=8YFLogxK
U2 - 10.1007/s00259-008-1023-7
DO - 10.1007/s00259-008-1023-7
M3 - Article
C2 - 19082590
AN - SCOPUS:62149145795
VL - 36
SP - 640
EP - 647
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
SN - 0340-6199
IS - 4
ER -