FDG-PET imaging in HIV-infected subjects: Relation with therapy and immunovirological variables

Giovanni Lucignani, Eva Orunesu, Miriam Cesari, Katia Marzo, Michela Pacei, Giulia Bechi, Andrea Gori, Sabrina Gaito, Mario Clerici, Arturo Chiti

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Purpose: To characterise tissue sites of immune activation and HIV replication we performed FDG-PET in ART-treated and ART-naive HIV-infected individuals. Specific aims were to establish whether HIV-infected patients can be differentiated on the basis of the detection of specific locations of viral replication, even in the presence of an apparently optimal immunovirological response to ART, and whether these FDG-PET findings can be related to immunovirological variables and AIDS history status. Patients and methods: Patients were divided into five groups as follows: subgroup A1 (full responders, n∈=∈8): current ART treatment, CD4+ T lymphocytes >500/mL, viral load 50,000 copies/mL; group C (ART-naïve, n∈=∈5): no current or previous ART treatment, increased viral load. Results: PET images revealed different patterns of FDG uptake. All ART-treated patients with either suppressed (

Original languageEnglish
Pages (from-to)640-647
Number of pages8
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume36
Issue number4
DOIs
Publication statusPublished - Apr 2009

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HIV
Viral Load
Therapeutics
Acquired Immunodeficiency Syndrome
T-Lymphocytes

Keywords

  • F-2-fluoro-2-deoxy-d-glucose
  • ART
  • FDG-PET
  • HIV
  • Imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

FDG-PET imaging in HIV-infected subjects : Relation with therapy and immunovirological variables. / Lucignani, Giovanni; Orunesu, Eva; Cesari, Miriam; Marzo, Katia; Pacei, Michela; Bechi, Giulia; Gori, Andrea; Gaito, Sabrina; Clerici, Mario; Chiti, Arturo.

In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 36, No. 4, 04.2009, p. 640-647.

Research output: Contribution to journalArticle

Lucignani, Giovanni ; Orunesu, Eva ; Cesari, Miriam ; Marzo, Katia ; Pacei, Michela ; Bechi, Giulia ; Gori, Andrea ; Gaito, Sabrina ; Clerici, Mario ; Chiti, Arturo. / FDG-PET imaging in HIV-infected subjects : Relation with therapy and immunovirological variables. In: European Journal of Nuclear Medicine and Molecular Imaging. 2009 ; Vol. 36, No. 4. pp. 640-647.
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