FDG PET Unveils the Course of Paraneoplastic Cerebellar Degeneration: A Semiquantitative Analysis

Federico Massa, Laura Filippi, Luana Benedetti, Silvia Morbelli, Flavio Nobili

Research output: Contribution to journalArticlepeer-review

Abstract

In paraneoplastic cerebellar degeneration (PCD), the standard diagnostic workup might be inconclusive, especially in seronegative subtypes. Brain 18F-FDG PET is an accurate supportive diagnostic tool in immune-mediated disorders, but findings in PCD are controversial. Semiquantitative analysis of 18F-FDG PET can meaningfully assist visual assessment in different neurological conditions and has been mainly applied to disclose regional hypometabolism. We describe a seronegative PCD associated with small cell lung cancer in which 18F-FDG PET semiquantitative analysis accurately disclosed the longitudinal pathological changes of brain metabolism occurring in the acute and posttreatment remission stages and paralleling clinical impairment and response to treatment.

Original languageEnglish
Pages (from-to)E327-E328
JournalClinical Nuclear Medicine
Volume46
Issue number6
DOIs
Publication statusPublished - 2021

Keywords

  • cerebellar degeneration
  • FDG PET
  • paraneoplastic syndrome
  • semiquantitative analysis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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