FDG-PET/CT findings highly suspicious for COVID-19 in an Italian case series of asymptomatic patients. European journal of nuclear medicine and molecular imaging

Lucia Setti, Margarita Kirienko, Serena Camilla Dalto, Manuela Bonacina, Emilio Bombardieri

Research output: Contribution to journalArticlepeer-review

Abstract

AIM: To illustrate the [18F]FDG-PET/CT findings in patients affected by cancer with clinical diagnosis of Covid-19 METHODS: We retrospectively reviewed the cases of patients who showed pulmonary involvement unrelated to cancer metastases on March 13 and 16 2020. We reviewed the scans, collected medical history, and exposure information. RESULTS: Among the 13 scans, we identified 5 cases with imaging findings suspicious for viral infection. Peripheral lung consolidations and/or ground-glass opacities in two or more lobes were found. Lung abnormalities displayed increased [18F]FDG uptake (SUVmax 4.3-11.3). All the patients on the day of PET/CT acquisition were asymptomatic, and they did not have fever or cough. In view of the PET/CT findings, home isolation, symptom surveillance, and treatment (in 3/5 patients) were indicated. At 1-week follow-up, 2/5 patients experienced the onset of mild respiratory symptoms. CONCLUSIONS: The [18F]FDG-PET/CT can identify probable Covid-19 disease in the absence or before symptoms onset and can guide patient management. Nuclear medicine staff needs to be aware of the possibility of contact with patients affected by the SARS-CoV-2 infection even if they do not present any symptom. Therefore, safety measures need to be adopted for other patients and hospital staff in order to block the spread of infection.
Original languageEnglish
Pages (from-to)1649-1656
Number of pages8
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume47
Issue number7
DOIs
Publication statusPublished - 2020

Keywords

  • Humans
  • Italy
  • Retrospective Studies
  • Fluorodeoxyglucose F18
  • Pandemics/prevention & control
  • *Coronavirus
  • *COVID-19
  • Betacoronavirus
  • COVID-19
  • *Asymptomatic
  • *FDG-PET/CT
  • *Imaging
  • *SARS-CoV-2
  • Coronavirus Infections/*diagnostic imaging/prevention & control
  • Equipment and Supplies/standards
  • Lung/*diagnostic imaging
  • Patient Safety/standards
  • Pneumonia, Viral/*diagnostic imaging/prevention & control
  • Positron Emission Tomography Computed Tomography/standards
  • SARS-CoV-2

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