FDG PET/CT predictive role in follicular lymphoma

Egesta Lopci, Lucia Zanoni, Arturo Chiti, Cristina Fonti, Ivan Santi, Pier Luigi Zinzani, Stefano Fanti

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Abstract

Purpose We present findings concerning 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) at endtreatment evaluation in follicular lymphoma (FL) in order to establish possible predictive factors for progression-free survival (PFS) and patient outcome. Methods We retrospectively analysed data from 91 consecutive FL patients (M:F=51:40, mean age 61) referred to our PET Unit at therapy completion: 38 with an indolent form (grade 1-2) and 53 with an aggressive FL (grade 3a and b) according to the World Health Organization (WHO) classification. A total of 148 FDG PET/CT scans were analysed and findings reported as positive or negative for disease. The overall response to treatment was assessed according to the revised International Workshop Criteria (IWC). The final outcome was defined as remission or disease by taking clinical, instrumental and histological data as standards of reference, with a mean follow-up period of 3 years (range 1-8). A statistical analysis was performed with respect to PFS and patient outcome for FDG PET result, tumour grading, Follicular Lymphoma International Prognostic Index (FLIPI), disease stage and number of relapses, on uni- and multivariate analyses, with p

Original languageEnglish
Pages (from-to)864-871
Number of pages8
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume39
Issue number5
DOIs
Publication statusPublished - May 2012

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Keywords

  • FDG PET/CT
  • Follicular lymphoma
  • Patient outcome
  • PFS
  • Predictive role

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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