Fear-Conditioning Mechanisms Associated with Trait Vulnerability to Anxiety in Humans

Iole Indovina, Trevor W. Robbins, Anwar O. Núñez-Elizalde, Barnaby D. Dunn, Sonia J. Bishop

Research output: Contribution to journalArticle

Abstract

Investigations of fear conditioning in rodents and humans have illuminated the neural mechanisms underlying cued and contextual fear. A critical question is how personality dimensions such as trait anxiety act through these mechanisms to confer vulnerability to anxiety disorders, and whether humans' ability to overcome acquired fears depends on regulatory skills not characterized in animal models. In a neuroimaging study of fear conditioning in humans, we found evidence for two independent dimensions of neurocognitive function associated with trait vulnerability to anxiety. The first entailed increased amygdala responsivity to phasic fear cues. The second involved impoverished ventral prefrontal cortical (vPFC) recruitment to downregulate both cued and contextual fear prior to omission (extinction) of the aversive unconditioned stimulus. These two dimensions may contribute to symptomatology differences across anxiety disorders; the amygdala mechanism affecting the development of phobic fear and the frontal mechanism influencing the maintenance of both specific fears and generalized anxiety.

Original languageEnglish
Pages (from-to)563-571
Number of pages9
JournalNeuron
Volume69
Issue number3
DOIs
Publication statusPublished - Feb 10 2011

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Fear
Anxiety
Amygdala
Anxiety Disorders
Aptitude
Conditioning (Psychology)
Neuroimaging
Cues
Personality
Rodentia
Down-Regulation
Animal Models
Maintenance

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Indovina, I., Robbins, T. W., Núñez-Elizalde, A. O., Dunn, B. D., & Bishop, S. J. (2011). Fear-Conditioning Mechanisms Associated with Trait Vulnerability to Anxiety in Humans. Neuron, 69(3), 563-571. https://doi.org/10.1016/j.neuron.2010.12.034

Fear-Conditioning Mechanisms Associated with Trait Vulnerability to Anxiety in Humans. / Indovina, Iole; Robbins, Trevor W.; Núñez-Elizalde, Anwar O.; Dunn, Barnaby D.; Bishop, Sonia J.

In: Neuron, Vol. 69, No. 3, 10.02.2011, p. 563-571.

Research output: Contribution to journalArticle

Indovina, I, Robbins, TW, Núñez-Elizalde, AO, Dunn, BD & Bishop, SJ 2011, 'Fear-Conditioning Mechanisms Associated with Trait Vulnerability to Anxiety in Humans', Neuron, vol. 69, no. 3, pp. 563-571. https://doi.org/10.1016/j.neuron.2010.12.034
Indovina I, Robbins TW, Núñez-Elizalde AO, Dunn BD, Bishop SJ. Fear-Conditioning Mechanisms Associated with Trait Vulnerability to Anxiety in Humans. Neuron. 2011 Feb 10;69(3):563-571. https://doi.org/10.1016/j.neuron.2010.12.034
Indovina, Iole ; Robbins, Trevor W. ; Núñez-Elizalde, Anwar O. ; Dunn, Barnaby D. ; Bishop, Sonia J. / Fear-Conditioning Mechanisms Associated with Trait Vulnerability to Anxiety in Humans. In: Neuron. 2011 ; Vol. 69, No. 3. pp. 563-571.
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