Feasibility and diagnostic agreement in teledermatopathology using a virtual slide system

Cesare Massone, H. Peter Soyer, Gian Piero Lozzi, Alessandro Di Stefani, Bernd Leinweber, Gerald Gabler, Masoud Asgari, Renata Boldrini, Leonardo Bugatti, Vincenzo Canzonieri, Gerardo Ferrara, Kazuo Kodama, Darius Mehregan, Franco Rongioletti, Shahbaz A. Janjua, Vahid Mashayekhi, Ismini Vassilaki, Bernhard Zelger, Borut Žgavec, Lorenzo CerroniHelmut Kerl

Research output: Contribution to journalArticlepeer-review


We investigated the feasibility and diagnostic agreement of a virtual slide system (VSS) in teledermatopathology. Forty-six biopsy specimens from inflammatory skin diseases were selected and scanned with a VSS at the Research Unit of Teledermatology, Medical University of Graz, Graz, Austria. Images were stored on a virtual slide server on which a specific Web application suited for telepathology (http://telederm.org/research/dermatopath/) runs. Twelve teleconsultants from 6 different countries reviewed the 46 cases, working directly on the Web application. Telediagnoses agreed with gold standard and conventional diagnosis with an average of 73% and 74%, respectively. Complete concordance among all teleconsultants with gold standard and conventional diagnosis was found in 20% of the cases. In 10 cases in which complete clinical data were missing, the average agreement of telediagnosis with gold standard diagnosis and conventional diagnosis decreased to 65% and 66%, respectively. Only 3 of 4 cases of inflammatory skin diseases were correctly diagnosed remotely with VSS. The system that we have used, despite its usability, is not completely feasible for teledermatopathology of inflammatory skin disease. Moreover, the performance seems to have been influenced by the availability of complete clinical data and by the intrinsic difficulty of the pathology of inflammatory skin diseases.

Original languageEnglish
Pages (from-to)546-554
Number of pages9
JournalHuman Pathology
Issue number4
Publication statusPublished - Apr 2007


  • Teledermatopathology
  • Telepathology
  • Virtual slide system

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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