Feasibility and long-term results of autologous PBSC transplantation in recurrent undifferentiated nasopharyngeal carcinoma

Mario Airoldi, Alberto De Crescenzo, Fulvia Pedani, Sara Marchionatti, Anna Maria Gabriele, Giovanni Succo, Giovanni Rosti, Cesare Bumma

Research output: Contribution to journalArticle

Abstract

Background. Recurrent undifferentiated nasopharyngeal carcinoma (UNPC) is a chemosensitive illness. Here we report long-term results of high-dose chemotherapy (HDC) as late intensification, with autologous peripheral blood stem cell (PBSC) support. Methods. Six patients (5 men, 1 woman; median age 41 years; median ECOG PS = 0) with recurrent UNPC (local, 2; local + nodal, 2; bone metastasis, 2) have been enrolled. All patients had been previously treated with neoadjuvant chemotherapy and radiotherapy; 3 of 4 local relapses had received a re-irradiation. Every patient received three courses of cisplatin + epirubicin and 1 cycle of epirubicin followed by PBSC collection. A median of 7.2 × 106/kg (range, 4.5-18) CD34+ cells were reinfused, HDC was according ICE scheme: ifosfamide, 2.5 g/m2/d, + carboplatin, 300 mg/m2/d, + VP-16, 300 mg/m2/d days 1 through 4. Results. After conventional chemotherapy, we had 1 CR (16%), 3 PR (50%), and 2 NC (34%). After HDC, we had 4 CR (66%), 1 PR (17%), and 1 MR (17%). Toxicity was manageable. After a median follow-up of 30 months (range, 14-50), two patients are alive without disease (34%), one is alive with bone disease (16%), and three (50%) died of disease at 16, 18, and 24 months. Conclusions. HDC has an acceptable toxicity, can convert PR in CR, and seems effective, with long-lasting CRs.

Original languageEnglish
Pages (from-to)799-803
Number of pages5
JournalHead and Neck
Volume23
Issue number9
DOIs
Publication statusPublished - 2001

Keywords

  • Autologous peripheral blood stem cell transplantation
  • Chemotherapy
  • Metastases
  • Nasopharyngeal cancer
  • Recurrence

ASJC Scopus subject areas

  • Otorhinolaryngology

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  • Cite this

    Airoldi, M., De Crescenzo, A., Pedani, F., Marchionatti, S., Gabriele, A. M., Succo, G., Rosti, G., & Bumma, C. (2001). Feasibility and long-term results of autologous PBSC transplantation in recurrent undifferentiated nasopharyngeal carcinoma. Head and Neck, 23(9), 799-803. https://doi.org/10.1002/hed.1114