Feasibility and yield of a new EUS histology needle: Results from a multicenter, pooled, cohort study

Julio Iglesias-Garcia, Jan Werner Poley, Alberto Larghi, Marc Giovannini, Maria Chiara Petrone, Ihab Abdulkader, Genevieve Monges, Guido Costamagna, Paolo Arcidiacono, Katharina Biermann, Guido Rindi, Erwan Bories, Claudio Dogloni, Marco Bruno, J. Enrique Dominguez-Muñoz

Research output: Contribution to journalArticle

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Abstract

Background: EUS-guided FNA is an efficacious technique for sampling intraintestinal and extraintestinal mass lesions. However, cytology has limitations to its final yield and accuracy, which may be overcome if histological specimens are provided to the pathologist. Objective: To evaluate feasibility, yield, and diagnostic accuracy of a newly developed 19-gauge, fine-needle biopsy (FNB) device. Design: Multicenter, pooled, cohort study. Setting: Five medical centers. Patients: This study involved 109 consecutive patients with 114 intraintestinal or extraintestinal mass lesions and/or peri-intestinal lymph nodes. Intervention: EUS-guided FNB (EUS-FNB) with a newly developed, 19-gauge, FNB device. Main Outcome Measurements: Percentage of cases in which pathologists classified the sample quality as optimal for histological evaluation and the overall diagnostic accuracy compared with a composite criterion-standard diagnosis. Results: We evaluated 114 lesions (mean [± standard deviation] size 35.1 ± 18.7 mm; 84 malignant [73.7%] and 30 [26.3%] benign). EUS-FNB was technically feasible in 112 lesions (98.24%). Sample quality was adequate for full histological assessment in 102 lesions (89.47%). In 98 cases (85.96%), diagnosis proved to be correct according to criterion-standard diagnosis. Sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy for diagnosis of malignancy were 90.2%, 100%, 100%, 78.9%, and 92.9%, respectively. Limitations: Use of a surrogate criterion-standard diagnosis, including clinical follow-up when no surgical specimens were available, mainly in benign diagnoses. Conclusion: Performing an EUS-FNB with a new 19-gauge histology needle is feasible for histopathology diagnosis of intraintestinal and extraintestinal mass lesions, offering the possibility of obtaining a core sample for histological evaluation in the majority of cases, with an overall diagnostic accuracy of over 85%.

Original languageEnglish
Pages (from-to)1189-1196
Number of pages8
JournalGastrointestinal Endoscopy
Volume73
Issue number6
DOIs
Publication statusPublished - Jun 2011

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Needles
Histology
Cohort Studies
Fine Needle Biopsy
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Equipment and Supplies
Cell Biology
Lymph Nodes
Sensitivity and Specificity
Neoplasms

ASJC Scopus subject areas

  • Gastroenterology
  • Radiology Nuclear Medicine and imaging

Cite this

Iglesias-Garcia, J., Poley, J. W., Larghi, A., Giovannini, M., Petrone, M. C., Abdulkader, I., ... Dominguez-Muñoz, J. E. (2011). Feasibility and yield of a new EUS histology needle: Results from a multicenter, pooled, cohort study. Gastrointestinal Endoscopy, 73(6), 1189-1196. https://doi.org/10.1016/j.gie.2011.01.053

Feasibility and yield of a new EUS histology needle : Results from a multicenter, pooled, cohort study. / Iglesias-Garcia, Julio; Poley, Jan Werner; Larghi, Alberto; Giovannini, Marc; Petrone, Maria Chiara; Abdulkader, Ihab; Monges, Genevieve; Costamagna, Guido; Arcidiacono, Paolo; Biermann, Katharina; Rindi, Guido; Bories, Erwan; Dogloni, Claudio; Bruno, Marco; Dominguez-Muñoz, J. Enrique.

In: Gastrointestinal Endoscopy, Vol. 73, No. 6, 06.2011, p. 1189-1196.

Research output: Contribution to journalArticle

Iglesias-Garcia, J, Poley, JW, Larghi, A, Giovannini, M, Petrone, MC, Abdulkader, I, Monges, G, Costamagna, G, Arcidiacono, P, Biermann, K, Rindi, G, Bories, E, Dogloni, C, Bruno, M & Dominguez-Muñoz, JE 2011, 'Feasibility and yield of a new EUS histology needle: Results from a multicenter, pooled, cohort study', Gastrointestinal Endoscopy, vol. 73, no. 6, pp. 1189-1196. https://doi.org/10.1016/j.gie.2011.01.053
Iglesias-Garcia, Julio ; Poley, Jan Werner ; Larghi, Alberto ; Giovannini, Marc ; Petrone, Maria Chiara ; Abdulkader, Ihab ; Monges, Genevieve ; Costamagna, Guido ; Arcidiacono, Paolo ; Biermann, Katharina ; Rindi, Guido ; Bories, Erwan ; Dogloni, Claudio ; Bruno, Marco ; Dominguez-Muñoz, J. Enrique. / Feasibility and yield of a new EUS histology needle : Results from a multicenter, pooled, cohort study. In: Gastrointestinal Endoscopy. 2011 ; Vol. 73, No. 6. pp. 1189-1196.
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abstract = "Background: EUS-guided FNA is an efficacious technique for sampling intraintestinal and extraintestinal mass lesions. However, cytology has limitations to its final yield and accuracy, which may be overcome if histological specimens are provided to the pathologist. Objective: To evaluate feasibility, yield, and diagnostic accuracy of a newly developed 19-gauge, fine-needle biopsy (FNB) device. Design: Multicenter, pooled, cohort study. Setting: Five medical centers. Patients: This study involved 109 consecutive patients with 114 intraintestinal or extraintestinal mass lesions and/or peri-intestinal lymph nodes. Intervention: EUS-guided FNB (EUS-FNB) with a newly developed, 19-gauge, FNB device. Main Outcome Measurements: Percentage of cases in which pathologists classified the sample quality as optimal for histological evaluation and the overall diagnostic accuracy compared with a composite criterion-standard diagnosis. Results: We evaluated 114 lesions (mean [± standard deviation] size 35.1 ± 18.7 mm; 84 malignant [73.7{\%}] and 30 [26.3{\%}] benign). EUS-FNB was technically feasible in 112 lesions (98.24{\%}). Sample quality was adequate for full histological assessment in 102 lesions (89.47{\%}). In 98 cases (85.96{\%}), diagnosis proved to be correct according to criterion-standard diagnosis. Sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy for diagnosis of malignancy were 90.2{\%}, 100{\%}, 100{\%}, 78.9{\%}, and 92.9{\%}, respectively. Limitations: Use of a surrogate criterion-standard diagnosis, including clinical follow-up when no surgical specimens were available, mainly in benign diagnoses. Conclusion: Performing an EUS-FNB with a new 19-gauge histology needle is feasible for histopathology diagnosis of intraintestinal and extraintestinal mass lesions, offering the possibility of obtaining a core sample for histological evaluation in the majority of cases, with an overall diagnostic accuracy of over 85{\%}.",
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AU - Poley, Jan Werner

AU - Larghi, Alberto

AU - Giovannini, Marc

AU - Petrone, Maria Chiara

AU - Abdulkader, Ihab

AU - Monges, Genevieve

AU - Costamagna, Guido

AU - Arcidiacono, Paolo

AU - Biermann, Katharina

AU - Rindi, Guido

AU - Bories, Erwan

AU - Dogloni, Claudio

AU - Bruno, Marco

AU - Dominguez-Muñoz, J. Enrique

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N2 - Background: EUS-guided FNA is an efficacious technique for sampling intraintestinal and extraintestinal mass lesions. However, cytology has limitations to its final yield and accuracy, which may be overcome if histological specimens are provided to the pathologist. Objective: To evaluate feasibility, yield, and diagnostic accuracy of a newly developed 19-gauge, fine-needle biopsy (FNB) device. Design: Multicenter, pooled, cohort study. Setting: Five medical centers. Patients: This study involved 109 consecutive patients with 114 intraintestinal or extraintestinal mass lesions and/or peri-intestinal lymph nodes. Intervention: EUS-guided FNB (EUS-FNB) with a newly developed, 19-gauge, FNB device. Main Outcome Measurements: Percentage of cases in which pathologists classified the sample quality as optimal for histological evaluation and the overall diagnostic accuracy compared with a composite criterion-standard diagnosis. Results: We evaluated 114 lesions (mean [± standard deviation] size 35.1 ± 18.7 mm; 84 malignant [73.7%] and 30 [26.3%] benign). EUS-FNB was technically feasible in 112 lesions (98.24%). Sample quality was adequate for full histological assessment in 102 lesions (89.47%). In 98 cases (85.96%), diagnosis proved to be correct according to criterion-standard diagnosis. Sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy for diagnosis of malignancy were 90.2%, 100%, 100%, 78.9%, and 92.9%, respectively. Limitations: Use of a surrogate criterion-standard diagnosis, including clinical follow-up when no surgical specimens were available, mainly in benign diagnoses. Conclusion: Performing an EUS-FNB with a new 19-gauge histology needle is feasible for histopathology diagnosis of intraintestinal and extraintestinal mass lesions, offering the possibility of obtaining a core sample for histological evaluation in the majority of cases, with an overall diagnostic accuracy of over 85%.

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