Feasibility evaluation of the application of Silicon Drift Detectors in studies of drug delivery in liver

R. Alberti, C. Fiorini, C. Guazzoni, T. Klatka, A. Longoni, R. Delfino, V. Lorusso, L. Pascolo, L. Vaccari, F. Arfelli, L. Mancini, R. H. Menk, L. Rigon, G. Tromba

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This work aims to assess the feasibility of studying the distribution of drugs and diagnostic agents in biological specimens by means of XRF detected with high-resolution and high sensitivity Silicon Drift Detectors. In the present study we have employed as diagnostic agent a gadolinium complex (Gadocoletic acid trisodium salt - B22956/1). The primary excitation beam was the light of the SYRMEP beamline of the Elettra synchrotron light source. For calibration purposes we analyzed solutions of the Gd complex in water at different dilutions. The minimum level of Gd detected is 5 μg/ml. We measured the Gd complex distribution in different organs (liver, kidney, spleen, lung) and in blood of mice at different times after a single injection of B22956 (250 mg/Kg body weight) and the Gd complex uptake in human liver-derived cells. This technique will allow the measure of pharmacokinetics and the study of the homogeneity of drug distribution inside organs providing a new tool in the development, follow-up and tracking of drug delivery in vitro.

Original languageEnglish
Title of host publicationIEEE Nuclear Science Symposium Conference Record
Pages1528-1532
Number of pages5
Volume3
DOIs
Publication statusPublished - 2007
Event2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD - San Diego, CA, United States
Duration: Oct 29 2006Nov 4 2006

Other

Other2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD
CountryUnited States
CitySan Diego, CA
Period10/29/0611/4/06

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Industrial and Manufacturing Engineering

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