Feasibility in the clinical setting of perfusion brain SPECT imaging employing a brain-dedicated gamma camera and the conjugate gradients with modified matrix reconstruction method

F. Nobili, P. Calvini, G. Taddei, P. Vitali, G. Mariani, G. Rodriguez

Research output: Contribution to journalArticle

Abstract

Abstract In the present study, we compared Tc-99m HMPAO single photon emission computed tomography (SPECT) brain images obtained using the conventional filtered backprojection (FBP) reconstruction method with the new reconstruction method of conjugate gradients with modified matrix (CGMM). The two methods were employed to generate SPECT images of a brain perfusion study in a 41 -year-old patient who had suffered from multiple embolisation of the right hemisphere. Marked improvement in spatial resolution was achieved by CGMM reconstruction as compared to FBP reconstruction; this considerably helped in defining grey matter structures and low-uptake white-matter areas, both in the normal cerebral areas and in the hemisphere that had been affected by stroke. Although the relatively long time still required by the CGMM procedure might be considered as a significant drawback to date, with the increasing diffusion of the new computer facilities the CGMM method can be proposed as a valuable alternative to the standard FBP technique in order to better recognise cerebral areas with different tracer uptake.

Original languageEnglish
Pages (from-to)373-377
Number of pages5
JournalItalian Journal of Neurological Sciences
Volume19
Issue number6
Publication statusPublished - 1998

Keywords

  • Cerebral spect
  • Conjugate gradients with modified matrix
  • Filtered backprojection

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology

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